Author | Wakimoto, Mayumi Duarte | |
Author | Camacho, Luiz Antonio Bastos | |
Author | Gonin, Michelle Luiza | |
Author | Brasil, Patrícia | |
Access date | 2019-02-19T11:46:49Z | |
Available date | 2019-02-19T11:46:49Z | |
Document date | 2018 | |
Citation | WAKIMOTO, Mayumi Duarte et al. Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children. Journal of Tropical Pediatrics, v. 64, p. 373–381, 2018. | pt_BR |
ISSN | 0142-6338 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31730 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Title | Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/tropej/fmx078 | |
Abstract | Background: More than half of the hospitalizations because of dengue in Brazil occurred in children <15 years of age in 2007 and 2008, an unexpected change in the epidemiological pattern. We sought to determine clinical and laboratory parameters associated with severity. Methods: A case-control study was conducted in three pediatric hospitals in Rio de Janeiro, Brazil; 233 laboratory-confirmed dengue patients were included: 69 cases and 164 controls. Specific clinical and laboratory factors were assessed using univariate and multivariate logistic regression models. Results: Lethargy [adjusted odds ratio (ORa): 9.15, 95% confidence interval (CI): 3.08–27.12], dyspnea (ORa: 8.24, 95% CI: 3.27–20.72) and abdominal pain (ORa: 6.78, 95% CI: 1.44–31.84)
were independently associated with severe dengue in children. Lethargy and dyspnea presented as early as 72 and 48 h, respectively, before shock. Conclusions: Abdominal pain and lethargy confirmed their role as warning signs, which along with dyspnea might be helpful in identifying cases progressing to severe dengue. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Secretaria Municipal de Saúde e Defesa Civil do Rio de Janeiro. Hospital Municipal Jesus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Case-control studies | pt_BR |
Subject | Dengue | pt_BR |
Subject | Pediatrics | pt_BR |
Subject | Severe dengue | pt_BR |
Subject | Shock | pt_BR |
e-ISSN | 1465-3664 | |
Embargo date | 2020-01-31 | |