| Author | Santos, Wagner B. R. | |
| Author | Melo, Marlange Almeida de Oliveira | |
| Author | Alves, Rafael da Silva | |
| Author | Brito, Renan Guedes de | |
| Author | Rabelo, Thallita Kelly | |
| Author | Prado, Lindaura da Silva | |
| Author | Silva, Virginia K. dos S. | |
| Author | Bezerra, Daniel Pereira | |
| Author | Menezes Filho, José E. R. de | |
| Author | Souza, Diego S. | |
| Author | Vasconcelos, Carla Maria Lins de | |
| Author | Scotti, Luciana | |
| Author | Scotti, Marcus Tullius | |
| Author | Lucca Júnior, Waldecy de | |
| Author | Quintans Júnior, Lucindo José | |
| Author | Guimarães, Adriana Gibara | |
| Access date | 2019-02-21T16:56:34Z | |
| Available date | 2019-02-21T16:56:34Z | |
| Document date | 2019 | |
| Citation | SANTOS, W. B. R. et al. p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents. Phytomedicine, p-1-33, 2019. | |
| ISSN | 0944-7113 | |
| URI | https://www.arca.fiocruz.br/handle/icict/31822 | |
| Sponsorship | Foundation for Research and Technological Innovation Support of the State of Sergipe (Fundação de Apoio à Pesquisa e Inovação Tecnológica do Estado de Sergipe/FAPITEC/SE), the National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil 449667/2014-6) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil). | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | open access | |
| Subject in Portuguese | Produtos naturais | pt_BR |
| Subject in Portuguese | Monoterpenos | pt_BR |
| Subject in Portuguese | Antinociceptivo | pt_BR |
| Subject in Portuguese | Hiperalgesia | pt_BR |
| Subject in Portuguese | Câncer | pt_BR |
| Title | p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents | en_US |
| Type | Preprint | |
| DOI | 10.1016/j.phymed.2019.152836 | |
| Abstract | Oncological pain is one of the most prevalent and difficult-to-treat symptoms in patients with cancer. p-cymene (PC) is a monoterpene found in more than 100 different plant species, endowed with various pharmacological properties - particularly antinociceptive. Hypothesis/Purpose: PC has antinociceptive effect in a model of oncologic pain due to the activation of the descending inhibitory pathway of pain. Study Design: A pre-clinical, longitudinal, blind and randomized study. Methods: Male Swiss mice were induced with S180 cells in the right hind paw, then treated daily with PC (12.5, 25 and 50 mg/kg, s.c.) and screened for mechanical hyperalgesia, spontaneous nociception, nociception induced by non-noxious palpation, tumor growth, changes in the neuromuscular function and existence of bone degradation in the tumor area. The effect of PC on Ca2+ currents (electrophysiological records), histological and neurochemical changes (immunofluorescence for Fos) were also evaluated. Results: PC reduced (p < 0.05) the mechanical hyperalgesia, the spontaneous (p < 0.001) and non-noxious palpation (p < 0.001) nociceptions, not changing the tumor development, neuromuscular function or histopathological aspects of the paw affected. PC reduced Fos expression in the spinal cord (p < 0.001) and increased this expression in the PAG (p < 0.05) and in the NRM (p < 0.01). PC decreased the density of calcium channel currents (p < 0.05). These results suggest the antinociceptive effect of PC on oncologic pain, probably acting in both ascending and descending pain pathways, and modulating the calcium channel currents in order to exert its effects. | en_US |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Postgraduate Program in Sciences Applied to Health. Lagarto, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Odontology. Lagarto, SE, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Paraíba. João Pessoa, PB, Brazil. | |
| Affilliation | Federal University of Paraíba. João Pessoa, PB, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Morphology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | |
| Affilliation | Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brazil. | |
| Subject | Natural products | en_US |
| Subject | Monoterpenes | en_US |
| Subject | Antinociceptive | en_US |
| Subject | Hyperalgesia | en_US |
| Subject | Cancer | en_US |
