| Author | Gonçalves, Daniela da Silva | |
| Author | Iturbe-Ormaetxe, Iñaki | |
| Author | Silva, Andrea Martins da | |
| Author | Telleria, Erich Loza | |
| Author | Rocha, Marcele Neves | |
| Author | Traub-Csekö, Yara M. | |
| Author | O'Neill, Scott L. | |
| Author | Sant'Anna, Maurício Roberto Viana | |
| Author | Moreira, Luciano Andrade | |
| Access date | 2019-03-07T13:32:11Z | |
| Available date | 2019-03-07T13:32:11Z | |
| Document date | 2019 | |
| Citation | GONÇALVES, Daniela da Silva et al. Wolbachia introduction into Lutzomyia longipalpis (Diptera: Psychodidae) cell lines and its effects on immune-related gene expression and interaction with Leishmania infantum. Parasites & Vectors, v. 12, n. 33, p. 1-13, 2019. | pt_BR |
| ISSN | 1756-3305 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31966 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Wolbachia | pt_BR |
| Subject in Portuguese | Lutzomyia longipalpis | pt_BR |
| Subject in Portuguese | Leishmania infantum | pt_BR |
| Title | Wolbachia introduction into Lutzomyia longipalpis (Diptera: Psychodidae) cell lines and its effects on immune-related gene expression and interaction with Leishmania infantum | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s13071-018-3227-4 | |
| Abstract | The leishmaniases are important neglected diseases caused by Leishmania spp. which are transmitted by sand flies, Lutzomyia longipalpis being the main vector of visceral leishmaniasis in the Americas. The methodologies for leishmaniasis control are not efficient, causing 1.5 million reported cases annually worldwide, therefore showing the need for development of novel strategies and interventions to control transmission of the disease. The bacterium Wolbachia pipientis is being used to control viruses transmitted by mosquitoes, such as dengue and Zika, and its introduction in disease vectors has been effective against parasites such as Plasmodium. Here we show the first successful establishment of Wolbachia into two different embryonic cell lines from L. longipalpis, LL-5 and Lulo, and analysed its effects on the sand fly innate immune system, followed by in vitro Leishmania infantum interaction. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Monash University. Institute of Vector-Borne Disease. World Mosquito Program. Clayton, Australia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitos e Vetores. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitos e Vetores. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitos e Vetores. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Monash University. Institute of Vector-Borne Disease. World Mosquito Program. Clayton, Australia. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Laboratório de Insetos Hematófagos. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Wolbachia | pt_BR |
| Subject | Lutzomyia longipalpis | pt_BR |
| Subject | Lulo cell | pt_BR |
| Subject | LL-5 cell | pt_BR |
| Subject | Leishmania infantum | pt_BR |
