| Author | Maya-Monteiro, Clarissa | |
| Author | Bozza, Patrícia T. | |
| Access date | 2019-03-09T18:42:57Z | |
| Available date | 2019-03-09T18:42:57Z | |
| Document date | 2008 | |
| Citation | MAYA-MONTEIRO, Clarissa M.; BOZZA, Patricia T. Leptin and mTOR: Partners in metabolism and inflammation. Cell Cycle, v. 7, n. 12, p. 1713-1717, June 2008. | pt_BR |
| ISSN | 1538-4101 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32019 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Leptina | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Corpos lipídicos | pt_BR |
| Subject in Portuguese | Macrófagos | pt_BR |
| Subject in Portuguese | Célula de espuma | pt_BR |
| Title | Leptin and mTOR: Partners in metabolism and inflammation | pt_BR |
| Type | Article | |
| DOI | 10.4161/cc.7.12.6157 | pt_BR |
| Abstract | Leptin is both a hormone/cytokine that plays a major role in the regulation of feeding and energy expenditure. Beyond its central role in the hypothalamus, leptin modulates peripheral tissues' responses to growth and storage based on nutrient availability, and it regulates the innate and adaptive immune responses. mTOR (mammalian Target of Rapamycin) is a core component of intracellular signaling for cellular growth, mRNA translation, and metabolism. Here, we review recent findings on the cross talk between mTOR and leptin signaling. Important roles for mTOR on leptin signaling have been established both in hypothalamic centers to control food intake and in peripheral cells to regulate lipid metabolism and inflammation. Leptin directly activates resident macrophages to form ADRP-enriched lipid droplets and enhances eicosanoid production via a mechanism that is dependent on activation of the PI3K/mTOR pathway. Leptin-induced mTOR activation may have implications for obesity-related pathophysiological conditions such as diabetes, cardiovascular disease and cancer. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leptin | pt_BR |
| Subject | mTOR | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Macrophage | pt_BR |
| Subject | ADRP | pt_BR |
| Subject | PI3K | pt_BR |
| Subject | Lipid bodies | pt_BR |
| Subject | Foam cell | pt_BR |
| e-ISSN | 1551-4005 | |
| Embargo date | 2022-01-01 | |
