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| Autor | Barral, Aldina Maria Prado | |
| Autor | Costa, Jackson Mauricio Lopes | |
| Autor | Bittencourt, Achilea Candida Lisboa | |
| Autor | Barral Netto, Manoel | |
| Autor | Carvalho, Edgar Marcelino de | |
| Fecha de acceso | 2019-03-15T14:19:02Z | |
| Fecha de disponibilización | 2019-03-15T14:19:02Z | |
| Fecha de publicación | 1995 | |
| Referencia | BARRAL, A.M. P. et al. Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathologic aspects. International Journal of Dermatology, v. 34, n. 7, p. 474-479, 1995. | pt_BR |
| ISSN | 0011-9059 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32109 | |
| Descripción | Manoel Barral Neto; Barral, Aldina Maria Prado. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | pt_BR |
| Promoción | United States Public Health Service Grant AI30639 and Brazilian National Research Gouncil (GNPq). | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Wiley | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Leishmaniose cutânea | pt_BR |
| Palabras clave en Portugués | Leishmania | pt_BR |
| Palabras clave en Portugués | Imunidade | pt_BR |
| Palabras clave en Portugués | Estudo clinico | pt_BR |
| Palabras clave en Portugués | Macrofagos | pt_BR |
| Palabras clave en Portugués | Humanos | pt_BR |
| Título | Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects | pt_BR |
| Tipo del documento | Article | pt_BR |
| Resumen en Inglés | Background. Diffuse cutaneous leishmaniasis (DCL) is a rare manifestation of human leishmaniasis, characterized by multiple, slowly progressive nodules or plaques without ulceration, involving almost the entire body. It has been suggested, that DCL results from a lack of cell-mediated immunity to leishmanial antigen, leading to uncontrolled parasite growth. Methods. We have performed detailed clinical, histopathologic, and immunologic investigations in six patients with DCL. Biopsies were taken from the nodules, processed, and examined for determination of the macrophagic pattern present, based on the intensity of vacuolation and the frequency of vacuolated cells, the parasite index, and the presence of eosinophils. Immunologically, patients were evaluated by their response to intradermal skin test to PPD or leishmania antigen, determination of antileishmania antibodies by immunofluorescent assay, and lymphocyte proliferation assay. Results. There seemed to be a negative relation between nodules and skin ulcerations, whereas the highest number of parasites were observed in patients with the greatest number of vacuolated macrophages. The delayed hypersensitivity skin test to leishmanial antigen was negative, and antileishmania IgG antibodies were positive in all patients. Conclusions. Although all cases fulfill the criteria for being classified as DCL, they present a wide spectrum. Three cases were clearly at the unresponsive pole, and three other cases belonged to the subpolar form of DCL, exhibiting varying weak signs of antiparasite responsiveness. | pt_BR |
| Afiliación | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Federal University of Maranhão. Faculty of Medicine. Department of Infectious and Parasitic Diseases. São Luís, MA, Brazil. | pt_BR |
| Afiliación | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Palavras clave en Inglês | Cutaneous leishmaniasis | pt_BR |
| Palavras clave en Inglês | Leishmaniasis | pt_BR |
| Palavras clave en Inglês | Immunity | pt_BR |
| Palavras clave en Inglês | Clinical study | pt_BR |
| Palavras clave en Inglês | Macrophages | pt_BR |
| Palavras clave en Inglês | Humans | pt_BR |
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