| Author | Gomes, Marilia B. | |
| Author | Matheus, Alessandra S. M. | |
| Author | Tibiriçá, Eduardo | |
| Access date | 2019-03-19T12:21:30Z | |
| Available date | 2019-03-19T12:21:30Z | |
| Document date | 2008 | |
| Citation | GOMES, Marilia B.; MATHEUS, Alessandra S. M.; TIBIRIÇÁ, Eduardo. Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: Which method to choose?. Microvascular Research, v.76, p.132-133, 2008. | pt_BR |
| ISSN | 0026-2862 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32144 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Diabetes tipo 1 | pt_BR |
| Subject in Portuguese | Função endotelial | pt_BR |
| Subject in Portuguese | Monitoramento de perfusão por laser-Doppler | pt_BR |
| Subject in Portuguese | Hiperemia reativa pós-oclusiva | pt_BR |
| Title | Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: which method to choose? | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.mvr.2008.04.003 | |
| Abstract | The evaluation of microvascular function is essential in the investigation of the pathophysiology of cardiometabolic diseases [Struijker-Boudier, H.A. et al., 2007. Evaluation of the microcirculation in hypertension and cardiovascular disease. Eur. Heart J. 28, 2834-2840]. In clinical research and practice, the study of microcirculation is of great value in the assessment of the effects of medical interventions and monitoring disease progression. It is well-known that patients with type 1 and 2 diabetes have microvascular dysfunction that results from numerous factors including hyperglycemia, oxidative stress and insulin resistance [Schalkwijk, C.G., Stehouwer, C.D., 2005. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin. Sci. (Lond). 109, 143-159]. Moreover, skin microvascular dysfunction in type 1 diabetes precedes symptoms of end-organ microvascular disease [Khan, F. et al., 2000. Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes. Diabetes Care 23, 215-220]. In this study, we assessed skin microvascular function of patients with type 1 diabetes using laser-Doppler perfusion monitoring (LDPM) coupled with physiological and pharmacological local vasodilator stimuli. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Unidade de Diabetes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Unidade de Diabetes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Unidade de Diabetes. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Laser-Doppler perfusion monitoring | pt_BR |
| Subject | Endothelial function | pt_BR |
| Subject | Type 1 diabetes | pt_BR |
| Subject | Post-occlusive reactive hyperemia | pt_BR |
| e-ISSN | 1095-9319 | |
| Embargo date | 2022-01-01 | |
