| Author | Castro, A. R. C. Motta | |
| Author | Martins, R. M. B. | |
| Author | Araujo, N. M. | |
| Author | Niel, C. | |
| Author | Facholi, G. B. | |
| Author | Lago, B. V. | |
| Author | Mello, F. C. A. | |
| Author | Gomes, S. A. | |
| Access date | 2019-03-19T16:27:09Z | |
| Available date | 2019-03-19T16:27:09Z | |
| Document date | 2008 | |
| Citation | CASTRO, A. R. C. Motta et al. Molecular epidemiology of hepatitis B virus in an isolated Afro-Brazilian community. Arch. Virol., v. 153, p. 2197-2205, 2008. | pt_BR |
| ISSN | 0304-8608 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32158 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Epidemiologia Molecular | pt_BR |
| Subject in Portuguese | Comunidade Afro-Brasileira | pt_BR |
| Title | Molecular epidemiology of hepatitis B virus in an isolated Afro-Brazilian community | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s00705-008-0237-0 | |
| Abstract | This study was conducted in an Afro-Brazilian, slave-descendant community with high (42.4%) hepatitis B virus (HBV) prevalence. Twenty (8.4%) out of the 239 subjects under study were HBsAg-positive, and HBV-DNA was detected in 59 (25%) individuals. A high rate (18.3%) of occult infection was therefore observed that was associated to low HBV loads (mean, 1.8 x 10(4) copies/ml) and to a specific amino acid substitution (C100Y) in the small surface antigen. Genotyping of 50 isolates showed that 43 (86%) were of subgenotype A1, one (2%) from subgenotype A2, and five (10%) from subgenotype D. Mixed genotypes A1 and E were observed in one (2%) sample. The genetic distance (0.8 +/- 0.3%) among the HBV/A1 isolates from the community was smaller than the intragroup divergence among A1 isolates from Brazil as a whole, but it was similar to that found between A2 isolates from different countries, suggesting that HBV/A1 was introduced in the community through different sources. The substitution W501R (polymerase), previously reported only in Gambia, was observed in 46% of the HBV/A1 isolates. The precore/core promoter region of HBsAg-positive isolates showed several substitutions that could explain the anti-HBe phenotype found in 18 of 20 (90%) of the HBsAg-positive subjects. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Departamento de Farmácia Bioquímica. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Departamento de Farmácia Bioquímica. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Hepatitis B virus | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | Afro-Brazilian community | pt_BR |
| e-ISSN | 1432-8798 | |
| Embargo date | 2022-01-01 | |
