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AutorMattos, Paulo Sérgio de Morais da Silveira
AutorNarendran, Gopalan
AutorAkrami, Kevan
AutorFukutani, Kiyoshi Ferreira
AutorAnbalagan, Selvaraj
AutorNayak, Kaustuv
AutorSubramanyam, Sudha
AutorSubramani, Rajasekaran
AutorVinhaes, Caian Leal de Azevedo
AutorSouza, Deivide Oliveira de
AutorAntonelli, Lis Ribeiro do Valle
AutorSatagopan, Kumar
AutorPorter, Brian O
AutorSher, Alan
AutorSwaminathan, Soumya
AutorSereti, Irini
AutorAndrade, Bruno de Bezerril
Data de acesso2019-03-20T13:02:59Z
Data de disponibilização2019-03-20T13:02:59Z
Data do publicação2019
CitaçãoMATTOS, Paulo Sérgio de Morais da Silveira et al. Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome. Scientific Reports, v. 9, p. 1-9, 2019.pt_BR
ISSN2045-2322pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/32172
FomentoIntramural Research Program of NIAID/NIH and by the Intramuralto- India grant from the US-India Co-operative research program. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). P.S.S.M. was supported by a PhD fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES. C.V. and D.S. are supported by FAPESBpt_BR
Idiomaengpt_BR
EditorNature Researchpt_BR
Direito Autoralopen accesspt_BR
Palavras-chaveSíndrome Inflamatória da Reconstituição Imunept_BR
Palavras-chaveTuberculosept_BR
Palavras-chaveTuberculose pulmonarpt_BR
Palavras-chaveHumanospt_BR
Palavras-chaveHIVpt_BR
TítuloDifferential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndromept_BR
Tipo do documentoArticlept_BR
DOI10.1038/s41598-018-37846-3
Resumo em InglêsImmune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy (ART) initiation. Phenotypic changes in T-cells during TB-IRIS and their relationship with systemic inflammation are not fully understood. In this prospective cohort study, we followed 48 HIV-positive patients with PTB from South India before and after ART initiation, examining T-lymphocyte subsets and inflammatory biomarkers in peripheral blood. Quantification of naïve (CD27+CD45RO-) as well as effector memory CD4+ T cells (CD27-CD45RO+) at weeks 2-6 after ART initiation could distinguish TB-IRIS from non-IRIS individuals. Additional analyses revealed that ART reconstituted different quantities of CD4+ T lymphocyte subsets with preferential expansion of CXCR3+ CCR6- cells in TB-IRIS patients. Moreover, there was an expansion and functional restoration of central memory (CD27+CD45RO+) CXCR3+CCR6- CD4+ lymphocytes and corresponding cytokines, with reduction in CXCR3-CCR6+ cells after ART initiation only in those who developed TB-IRIS. Together, these observations trace a detailed picture of CD4+ T cell subsets tightly associated with IRIS, which may serve as targets for prophylactic and/or therapeutic interventions in the future.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.pt_BR
AfiliaçãoNational Institute for Research in Tuberculosis. Chennai, India.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / University of California. Department of Medicine. Division of Infectious Diseases. San Diego, United States of America.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.pt_BR
AfiliaçãoNational Institute for Research in Tuberculosis. Chennai, India.pt_BR
AfiliaçãoNational Institute for Research in Tuberculosis. Chennai, India.pt_BR
AfiliaçãoNational Institute for Research in Tuberculosis. Chennai, India.pt_BR
AfiliaçãoNational Institute for Research in Tuberculosis. Chennai, India.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.pt_BR
AfiliaçãoGovernment Hospital of Thoracic Medicine. Tambaram, Chennai, India.pt_BR
AfiliaçãoNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunoregulation. Clinical HIV Pathogenesis Section. Bethesda, Maryland, United States of America.pt_BR
AfiliaçãoNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, Maryland, United States of America.pt_BR
AfiliaçãoNational Institute for Research in Tuberculosis. Chennai, India.pt_BR
AfiliaçãoGovernment Hospital of Thoracic Medicine. Tambaram, Chennai, India.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Trust Centre for Infectious Disease Research in Africa. Cape Town, Republic of South Africa / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Division of Department of Medicine. Infectious Diseases. Nashville, Tennessee, United States of America.pt_BR
Palavras-chave em inglêsImmune Reconstitution Inflammatory Syndromept_BR
Palavras-chave em inglêsTuberculosispt_BR
Palavras-chave em inglêsPulmonary tuberculosispt_BR
Palavras-chave em inglêsHumanspt_BR
Palavras-chave em inglêsHIVpt_BR


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