| Author | Hatagima, Ana | |
| Author | Costa, Emmerson C.B. | |
| Author | Marques, Christiane F.S. | |
| Author | Koifman, Rosalina J. | |
| Author | Bofetta, Paolo | |
| Author | Koifman, Sergio | |
| Access date | 2019-03-20T13:55:03Z | |
| Available date | 2019-03-20T13:55:03Z | |
| Document date | 2008 | |
| Citation | HATAGIMA, Ana et al. Glutathione S-transferase polymorphisms and oral cancer: A case-control study in Rio de Janeiro, Brazil. Oral Oncology, v. 44, n. 2, p.200-207, 2008. | pt_BR |
| ISSN | 1368-8375 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32176 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Epidemiologia molecular | pt_BR |
| Subject in Portuguese | Polimorfismo Genético | pt_BR |
| Subject in Portuguese | Neoplasias Bucais | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Title | Glutathione S-transferase polymorphisms and oral cancer: A case-control study in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.oraloncology.2007.02.001 | |
| Abstract | Summary: This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and
GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro. DNA
extracted from white blood cells of 231 oral cancer patients and 212 hospital controls was analyzed
by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP)
methods. GSTM1 polymorphism distribution was different between cases and controls
(P = 0.006), with an overrepresentation of GSTM1 A/B genotype in controls. GSTM1 A/B individuals
were at decreased oral cancer risk (OR = 0.08; 95% CI = 0.05–0.62). No statistically significant
association was observed for GSTT1 and GSTP1 polymorphisms. Differences in the GSTM1
and GSTT1 null genotype frequencies were observed between individuals of European origin and
African origin, but these genotypes do not seem to influence the risk of oral cancer. Therefore,
these results do not support the hypothesis of increased risk of GSTP1 G/G, GSTM1 or GSTT1
null genotypes for developing cancer in oral cavity, but the GSTM1 A/B genotype emerged as
a protective factor. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | International Agency for Research on Cancer. Lyon, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | Oral cancer | pt_BR |
| Subject | Genetic polymorphism | pt_BR |
| Subject | GSTM1 | pt_BR |
| Subject | GSTT1 | pt_BR |
| Subject | GSTP1 | pt_BR |
| Subject | Brazil | pt_BR |
| DeCS | Neoplasias Bucais | pt_BR |
| DeCS | Glutationa S-Transferase pi | pt_BR |
| e-ISSN | 1879-0593 | |
| Embargo date | 2022-01-01 | |
