| Author | Sabino, Bruno | |
| Author | Lessa, Marcos A. | |
| Author | Nascimento, Alessandro R. | |
| Author | Rodrigues, Carlos A. B. | |
| Author | Henriques, Maria das Graças | |
| Author | Garzoni, Luciana R. | |
| Author | Levy, Bernard I. | |
| Author | Tibiriçá, Eduardo | |
| Access date | 2019-03-20T14:13:49Z | |
| Available date | 2019-03-20T14:13:49Z | |
| Document date | 2008 | |
| Citation | SABINO, Bruno et al. Effects of Antihypertensive Drugs on Capillary Rarefaction in Spontaneously Hypertensive Rats: Intravital Microscopy and Histologic Analysis. J. Cardiovasc. Pharmacol., v. 51, n. 4, Apr. 2008. | pt_BR |
| ISSN | 0160-2446 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32178 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Bloqueador de canal de cálcio | pt_BR |
| Subject in Portuguese | Capilaroscopia intravital | pt_BR |
| Subject in Portuguese | Antagonista do receptor AT1 | pt_BR |
| Subject in Portuguese | Hipertensão | pt_BR |
| Title | Effects of Antihypertensive Drugs on Capillary Rarefaction in Spontaneously Hypertensive Rats: Intravital Microscopy and Histologic Analysis | pt_BR |
| Type | Article | |
| Abstract | We investigated the effects of chronic oral antihypertensive
treatment on functional and structural capillary rarefaction in
spontaneously hypertensive rats (SHR). Wistar Kyoto rats (WKY)
were used as a normotensive control group. In untreated rats, intravital
videomicroscopy showed that functional capillary density was
lower in SHR skeletal muscle (WKY 395 6 17 and SHR 258 6 13
capillaries/mm2, P , 0.01) and ear skin (WKY 391 6 18 and SHR
210 6 15 capillaries/mm2, P , 0.01). A linear relationship was seen
between skeletal muscle and skin capillary densities (r = 0.654, P ,
0.0001). Histologic analysis showed that SHR had a lower capillaryto-
fiber ratio in the skeletal muscle (WKY 1.74 6 0.08 and SHR
1.40 6 0.06, P , 0.01). Capillary volume density-to-fiber volume
density ratio in the left ventricle of SHR was also reduced (WKY
0.55 6 0.09 and SHR 0.42 6 0.09, P , 0.01). The animals were
treated with the angiotensin-converting enzyme (ACE) inhibitor
enalapril, the angiotensin II type I receptor (AT1) receptor antagonist
losartan, the b-blocker atenolol, or the calcium channel blocker
nifedipine, resulting in similar reductions in systolic blood pressure
(19.8%, 19.1%, 17.4%, and 18.2%, respectively, P . 0.05). Atenolol
did not induce any change in functional capillary density of SHR.
Losartan and nifedipine completely reversed functional capillary
rarefaction in both muscle and cutaneous tissues, whereas enalapril
significantly increased functional capillary density only in the skin.
The skeletal muscle capillary-to-fiber ratio was normalized by enalapril,
losartan, and nifedipine. Treatments with enalapril or losartan
normalized the cardiac structural capillary rarefaction of SHRs,
whereas atenolol and nifedipine had no effect. Our results suggest
that different pharmacologic classes of antihypertensive drugs with
similar effect on blood pressure differ in terms of their effect on the
microcirculation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Instituto de Tecnologia de Drogas. Departamento de Farmacologia Aplicada. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto de Tecnologia de Drogas. Departamento de Farmacologia Aplicada. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Hópital Lariboisiére. Cardiovascular Research Center. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Capillary rarefaction | pt_BR |
| Subject | Intravital capillaroscopy | pt_BR |
| Subject | SHR | pt_BR |
| Subject | AT1 receptor antagonist | pt_BR |
| Subject | b-blocker | pt_BR |
| Subject | ACE inhibitor | pt_BR |
| Subject | Calcium channel blocker | pt_BR |
| DeCS | Ratos Endogâmicos SHR | pt_BR |
| e-ISSN | 1533-4023 | |
| Embargo date | 2022-01-01 | |
