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AutorBarbosa Junior, Aryon de Almeida
AutorSilva, Tania Correia
AutorPatel, Balmukund Niljay
AutorSantos, M. I. Ribeiro
AutorWakamatsu, A.
AutorAlves, Venâncio Avancini Ferreira
Fecha de acceso2019-03-28T12:29:14Z
Fecha de disponibilización2019-03-28T12:29:14Z
Fecha de publicación1994
ReferenciaBARBOSA JUNIOR, Aryon de Almeida et al. Demonstration of mycobacterial antigens in skin biopsies from suspected leprosy cases in the absence of bacilli. Pathology Research and Practice, v. 190, p. 782-785, 1994.pt_BR
ISSN0344-0338pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/32262
Idiomaengpt_BR
EditorElsevierpt_BR
Derechos de autorrestricted accesspt_BR
Palabras clave en PortuguésHanseníasept_BR
Palabras clave en PortuguésAntígeno Micobacterianopt_BR
Palabras clave en PortuguésImuno-Histoquímicapt_BR
TítuloDemonstration of Mycobacterial Antigens in Skin Biopsies from Suspected Leprosy Cases in the Absence of Bacillipt_BR
Tipo del documentoArticle
DOI10.1016/S0344-0338(11)80425-5pt_BR
Resumen en InglésSkin-biopsies from fifty-six patients suspected of early leprosy from Bahia State, Brazil, were examined histopathologically. The Fite-Faraco staining failed to demonstrate acid-fast bacilli in this material. The prominent features of the lesions were inflammation of the neurovascular bundles and sometimes inflammation of the skin appendages. The non-specific infiltrate was predominantly composed of histiocytes and lymphocytes. In 41 cases (73.2 %) epidermal atrophy was also present. The avidin-biotin peroxidase technique was used with primary antibodies to detect bacillary antigens (anti-BCG serum) and nerve branches (anti-S-100 protein serum). Immunohistochemical detection of bacillary antigens using the anti-BCG serum was positive in 28 cases (50 %). A positive staining for S-100 protein was observed in 40 cases (71.4 %) in dendritic antigen-presenting cells of the skin. The detection of bacillary antigens, together with the clear demonstration of nerve bundles enhanced our capacity to fulfill morphologic criteria for the diagnosis of early leprosy. Our observations indicate that the use of immunohistochemical methods represent a useful tool for the early diagnosis of leprosy.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónInstituto Adolfo Lutz. São Paulo, SP, Brasil.pt_BR
AfiliaciónInstituto Adolfo Lutz. São Paulo, SP, Brasil.pt_BR
Palavras clave en InglêsLeprosypt_BR
Palavras clave en InglêsMycobacterial antigenpt_BR
Palavras clave en InglêsImmunohistochemistrypt_BR


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