| Author | Otto, Thomas D. | |
| Author | Guimarães, Ana Carolina R. | |
| Author | Degrave, Wim M. | |
| Author | Miranda, Antonio B. de | |
| Access date | 2019-03-28T12:42:42Z | |
| Available date | 2019-03-28T12:42:42Z | |
| Document date | 2008 | |
| Citation | OTTO, Thomas D. et al. AnEnPi: identification and annotation of analogous enzymes. BMC Bioinformatics, v. 9, n. 544, 9p, Dec. 2008. | pt_BR |
| ISSN | 1471-2105 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32263 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Enzimas análogas | pt_BR |
| Subject in Portuguese | Identificação | pt_BR |
| Subject in Portuguese | Pipeline de Enzimas Análogas | pt_BR |
| Subject in Portuguese | AnEnPi | pt_BR |
| Title | AnEnPi: identification and annotation of analogous enzymes | pt_BR |
| Type | Article | |
| DOI | 10.1186/1471-2105-9-544 | |
| Abstract | Enzymes are responsible for the catalysis of the biochemical reactions in metabolic
pathways. Analogous enzymes are able to catalyze the same reactions, but they present no
significant sequence similarity at the primary level, and possibly different tertiary structures as well.
They are thought to have arisen as the result of independent evolutionary events. A detailed study
of analogous enzymes may reveal new catalytic mechanisms, add information about the origin and
evolution of biochemical pathways and disclose potential targets for drug development. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil / Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Analogous enzymes | pt_BR |
| Subject | Identification | pt_BR |
| Subject | Analogous Enzyme Pipeline | pt_BR |
| Subject | AnEnPi | pt_BR |
