| Author | Tuon, Felipe Francisco | |
| Author | Silva, Adriano Gomes da | |
| Author | Cruz, Alda Maria da | |
| Author | Duarte, Maria Irma Seixas | |
| Author | Amato Neto, Vicente | |
| Author | Amato, Valdir Sabbaga | |
| Access date | 2019-04-02T13:01:37Z | |
| Available date | 2019-04-02T13:01:37Z | |
| Document date | 2008 | |
| Citation | TUON, Felipe Francisco et al. Local immunological factors associated with recurrence of mucosal leishmaniasis. Clinical Immunology, v. 128, n. 1, p. 442-446, 2008. | pt_BR |
| ISSN | 1521-6616 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32325 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Leishmaniose tegumentar americana | pt_BR |
| Subject in Portuguese | Leishmaniose mucosa | pt_BR |
| Subject in Portuguese | Recorrência | pt_BR |
| Subject in Portuguese | Infiltrado inflamatório da lesão | pt_BR |
| Subject in Portuguese | Subconjuntos de células T | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Title | Local immunological factors associated with recurrence of mucosal leishmaniasis | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.clim.2008.05.007 | |
| Abstract | Recurrence of mucosal leishmaniasis (ML) is frequent, but the causative mechanisms are unknown. Our aim was to compare cellular and cytokine patterns of lesions from ML that evolved to recurrence or cure in order to determine the risk factor associated with recurrence. Lesions were evaluated by immunohistochemistry before and after therapy, and patients were followed-up for five years. Higher levels of CD4(+) T and IFN-gamma-producing cells were detected in active lesions and decreased after therapy. Macrophages and IL-10 were markedly increased in cured patients. Conversely, CD8(+) T and NK cells were higher in relapsed than in cured cases. Notably, a decrease in these cells in addition to decreased IL-10 and IFN-gamma was also observed after therapy. These data suggest that exacerbated CD8(+) activity, in addition to a poor regulatory response, could underlie an unfavorable fate with regard to ML. These markers may be useful for predicting the prognosis of ML in lesion studies. | pt_BR |
| Affilliation | Universidade de São Paulo. Departamento de Doenças Infecciosas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratório da Disciplina de Patologia da Doença Transmissível. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Hospital das Clínicas. Laboratório de Investigação Médica - Parasitologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Hospital das Clínicas. Clínica de Doenças Infecciosas e Parasitárias. São Paulo, SP, Brasil. | pt_BR |
| Subject | American tegumentary leishmaniasis | pt_BR |
| Subject | Mucosal leishmaniasis | pt_BR |
| Subject | Lesion inflammatory infiltrate | pt_BR |
| Subject | Recurrence | pt_BR |
| Subject | T-cell subsets | pt_BR |
| Subject | Cytokines | pt_BR |
| e-ISSN | 1521-7035 | |
| Embargo date | 2022-01-01 | |
