| Author | Salluh, Jorge I. F. | |
| Author | Póvoa, Pedro | |
| Author | Soares, Márcio | |
| Author | Faria Neto, Hugo Caire C. | |
| Author | Bozza, Fernando A. | |
| Author | Bozza, Patrícia T. | |
| Access date | 2019-04-04T12:37:41Z | |
| Available date | 2019-04-04T12:37:41Z | |
| Document date | 2008 | |
| Citation | SALLUH, Jorge I. F. et al. The role of corticosteroids in severe community-acquired pneumonia: a systematic review. Critical Care, v. 12, n. 3, p. 1-7, 2008. | pt_BR |
| ISSN | 1364-8535 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32356 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Corticosteróides | pt_BR |
| Subject in Portuguese | Pacientes graves | pt_BR |
| Subject in Portuguese | Pneumonia | pt_BR |
| Subject in Portuguese | Revisão sistemática | pt_BR |
| Subject in Portuguese | Impacto | pt_BR |
| Subject in Portuguese | Avaliação | pt_BR |
| Title | The role of corticosteroids in severe community-acquired pneumonia: a systematic review | pt_BR |
| Type | Article | |
| DOI | 10.1186/cc6922 | |
| Abstract | Introduction: The purpose of this review was to evaluate the impact of corticosteroids on the outcomes of patients with severe community-acquired pneumonia (CAP). Methods: We performed a systematic MEDLINE, Cochrane database, and CINAHL search (1966 to November 2007) to
identify full-text publications that evaluated the use of corticosteroids in CAP. Results: An initial literature search yielded 109 articles, and 105
studies were excluded after the first analysis. We found four studies eligible for analysis. On the basis of their results, the use of corticosteroids as adjunctive therapy in severe CAP should be categorized as a weak recommendation (two studies) and a strong recommendation (two studies) with either low- or moderate-quality evidence. However, no evidence of adverse outcomes or harm is present in the evaluated studies. Conclusion: According to the GRADE system, available studies do not support the recommendation of corticosteroids as a standard of care for patients with severe CAP. Further randomized controlled trials with this aim should enroll a larger number of severely ill patients. However, in patients needing
corticosteroids, it may be reasonable to conclude that corticosteroid administration is safe in patients with severe infections receiving antimicrobial therapy. | pt_BR |
| Affilliation | Instituto Nacional de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de São Francisco Xavier. Centro Hospitalar de Lisboa Ocidental. Unidade de Terapia Intensiva Médica. Lisboa, Portugal. | pt_BR |
| Affilliation | Instituto Nacional de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Corticosteroids | pt_BR |
| Subject | Pneumonia | pt_BR |
| Subject | Severe community-acquired | pt_BR |
| Subject | Systematic review | pt_BR |
| Subject | Evalution | pt_BR |
| Subject | Impact | pt_BR |
| e-ISSN | 1466-609X | |
