| Author | Yende, Sachin | |
| Author | Austin, Shamly | |
| Author | Rhodes, Andrew | |
| Author | Finfer, Simon | |
| Author | Opal, Steven | |
| Author | Thompson, Taylor | |
| Author | Bozza, Fernando A. | |
| Author | LaRosa, Steven P. | |
| Author | Ranieri, V. Marco | |
| Author | Angus, Derek C. | |
| Access date | 2019-04-08T14:22:41Z | |
| Available date | 2019-04-08T14:22:41Z | |
| Document date | 2016 | |
| Citation | YENDE, Sachin et al. Long-term quality of life among survivors of several sepsis: analyses of two international trialals. Critical Care Medicine, v. 44, n. 8, p. 1461-1467, Aug. 2016. | pt_BR |
| ISSN | 0090-3493 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32408 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | open access | pt_BR |
| Title | Long-term quality of life among survivors of severe sepsis: analyses of two international trials | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1097/CCM.0000000000001658 | |
| Abstract | Objective: To describe quality of life (QoL) among sepsis survivors. Design: Secondary analyses of 2 international, randomized clinical trials (ACCESS [derivation cohort] and PROWESS-SHOCK [validation cohort]). Patients: Adults with severe sepsis admitted to the intensive care unit. We analyzed only patients who were functional and living at home without help before sepsis hospitalization (n=1,143 and 987 from ACCESS and PROWESS-SHOCK). Measurements and Main Results: In ACCESS and PROWESS-SHOCK, the average age of patients living at home independently was 63 and 61 years; 400 (34.9%) and 298 (30.2%) died by 6 months. In ACCESS, 580 patients had a QoL measured using EQ-5D at 6 months. Of these, 41.6% could not live independently (22.7% were home but required help, 5.1% were in nursing home or rehabilitation facilities, and 5.3% were in acute care hospitals). Poor QoL at 6 months, as evidenced by problems in mobility, usual activities, and self-care domains were reported in 37.4%, 43.7%, and 20.5%, respectively, and the high incidence of poor QoL was also seen in patients in PROWESS-SHOCK. Over 45%of patients with mobility and self-care problems at 6 months in ACCESS died or reported persistent problems at 1 year. Conclusions: Among individuals enrolled in a clinical trial who lived independently prior to severe sepsis, one third had died and of those who survived, a further one third had not returned to independent living by 6 months. Both mortality and QoL should be considered when designing new interventions and considering endpoints for sepsis trials. | pt_BR |
| Affilliation | University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA / Veterans Affairs Pittsburgh Healthcare System. Pittsburg, PA, USA. | pt_BR |
| Affilliation | University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA / Gateway Health. Research and Development, Quality Improvement Department. Pittsburgh PA, USA. | pt_BR |
| Affilliation | St. George’s University Hospitals NHS Foundation Trust. Adult Critical Care. London, UK. | pt_BR |
| Affilliation | University of Sydney. The George Institute for Global Health. Sydney, NSW, Australia. | pt_BR |
| Affilliation | Alpert Medical School of Brown University. Infectious Disease Division. Pawtucket, RI, USA. | pt_BR |
| Affilliation | Massachusetts General Hospital. Pulmonary and Critical Care Division. Boston, MA, USA. | pt_BR |
| Affilliation | University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Lahey Health System. Beverly Hospital. Beverly, MA, USA. | pt_BR |
| Affilliation | University Sapienza of Rome. Policlino Umberto I Hospital. Department of Anesthesia and Intensive Care Medicine. Rome, Italy. | pt_BR |
| Affilliation | University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA. | pt_BR |
| Subject | Survivors of severe sepsis | pt_BR |
| Subject | Clinical trials | pt_BR |
| Embargo date | 2020-04-08 | |
