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| Autor | Figueiredo, Marcela Barbosa de | |
| Autor | Genta, Fernando Ariel | |
| Autor | Garcia, Eloi de Souza | |
| Autor | Azambuja, Patrícia de | |
| Fecha de acceso | 2019-04-16T12:35:43Z | |
| Fecha de disponibilización | 2019-04-16T12:35:43Z | |
| Fecha de publicación | 2008 | |
| Referencia | FIGUEIREDO, Marcela Barbosa de et al. Lipid mediators and vector infection: Trypanosoma rangeli inhibits Rhodnius prolixus hemocyte phagocytosis by modulation of phospholipase A2 and PAF-acetylhydrolase activities. Journal of Insect Physiology, v. 54, n. 12, p. 1528-1537, Dec. 2008. | |
| ISSN | 0022-1910 | |
| URI | https://www.arca.fiocruz.br/handle/icict/32509 | |
| Descripción | Produção científica do Laboratório de Bioquímica e Fisiologia de Insetos. | pt_BR |
| Idioma | eng | en_US |
| Editor | Elsevier | |
| Derechos de autor | restricted access | |
| Palabras clave en Portugués | Rhodnius prolixus | pt_BR |
| Palabras clave en Portugués | Trypanosoma rangeli | pt_BR |
| Palabras clave en Portugués | Ácido Araquidônico | pt_BR |
| Palabras clave en Portugués | Fosfolipases A2 | pt_BR |
| Título | Lipid mediators and vector infection: Trypanosoma rangeli inhibits Rhodnius prolixus hemocyte phagocytosis by modulation of phospholipase A2 and PAF-acetylhydrolase activities | en_US |
| Tipo del documento | Article | |
| DOI | 10.1016/j.jinsphys.2008.08.013 | |
| Resumen en Inglés | In this work we investigated the effects of Trypanosoma rangeli infection through a blood meal on the hemocyte phagocytosis in experiments using the 5th instar larvae of Rhodnius prolixus. Hemocyte phagocytic activity was strongly blocked by oral infection with the parasites. In contrast, hemocyte phagocytosis inhibition caused by T. rangeli infection was rescued by exogenous arachidonic acid (20 microg/insect) or platelet activating factor (PAF; 1 microg/insect) applied by hemocelic injection. Following the oral infection with the protozoan we observed significant attenuation of phospholipase A2 (PLA2) activities in R. prolixus hemocytes (cytosolic PLA2: cPLA2, secreted PLA2: sPLA2 and Ca+2-independent PLA2: iPLA2) and enhancement of sPLA2 activities in cell-free hemolymph. At the same time, the PAF-acetyl hydrolase (PAF-AH) activity in the cell-free hemolymph increased considerably. Our results suggest that T. rangeli infection depresses eicosanoid and insect PAF analogous (iPAF) pathways giving support to the role of PLA2 in the regulation of arachidonic acid and iPAF biosynthesis and of PAF-AH by reducing the concentration of iPAF in R. prolixus. This illustrates the ability of T. rangeli to modulate the immune responses of R. prolixus to favor its own multiplication in the hemolymph. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil. | |
| Palavras clave en Inglês | Rhodnius prolixus | en_US |
| Palavras clave en Inglês | Trypanosoma rangeli | en_US |
| Palavras clave en Inglês | Hemocytes phagocytosis | en_US |
| Palavras clave en Inglês | Arachidonic acid | en_US |
| Palavras clave en Inglês | Phospholipase A2 | en_US |
| Palavras clave en Inglês | PAF-acetyl hydrolase | en_US |
| e-ISSN | 1879-1611 | |
| Fecha de embargo | 2030-12-31 |
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