| Author | Andrade, Rodrigo Guimarães | |
| Author | Gotardo, Bruna Magalhães | |
| Author | Assis, Bárbara Cristina Alves de | |
| Author | Mengele Junior, José Orivaldo | |
| Author | Andrade, Zilton de Araújo | |
| Access date | 2011-10-04T20:58:54Z | |
| Available date | 2011-10-04T20:58:54Z | |
| Document date | 2005 | |
| Citation | ANDRADE, R. G. et al. Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Memórias do Instituto Oswaldo Cruz, v. 99, n. 7, p. 703-707, nov. 2004. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/3250 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Systhematized septal fibrosis of the liver can be induced in rats either by repeated intraperitoneal injections of pig-serum or by Capillaria hepatica infection. The relationship between these two etiological factors, as far as hepatic fibrosis is concerned, is not known, and present investigation attempts to investigate it. C. hepatica-induced septal fibrosis of the liver was considerably inhibited in rats previously rendered tolerant to pig-serum. Pig-serum-tolerant rats developed antibodies against pig-serum when infected with C. hepatica, but this did not happen when the infection occurred in normal rats. On the other hand, anti-C. hepatica antibodies failed to recognize any epitope in pig-serum, by Western blot. However, no evidence of an immunological cross reactivity was found, at least at the humoral level. Alternatively, cell-mediated mechanisms may be involved, and further investigations are warranted. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. | pt_BR |
| Subject | Pig-serum model | pt_BR |
| Subject | Capillaria hepatica | pt_BR |
| Subject | Hepatic septal fibrosis | pt_BR |
| DeCS | Anticorpos Anti-Helmínticos | pt_BR |
| DeCS | Antígenos de Helmintos | pt_BR |
| DeCS | Capillaria | pt_BR |
| DeCS | Infecções por Enoplida | pt_BR |
| DeCS | Tolerância Imunológica | pt_BR |
| DeCS | Cirrose Hepática Experimental | pt_BR |
| DeCS | Hepatopatias Parasitárias | pt_BR |
| DeCS | Western Blotting | pt_BR |
| DeCS | Ratos Wistar | pt_BR |
| DeCS | ELISA | pt_BR |
