| Author | Cavalher-Machado, S. C. | |
| Author | Cuman, R. K. N. | |
| Author | Sartoretto, J. L. | |
| Author | Martins, J. O. | |
| Author | Lima, W. Tavares de | |
| Author | Martins, M. A. | |
| Author | Silva, P. M. R. | |
| Author | Sannomiya, P. | |
| Access date | 2019-04-16T12:50:41Z | |
| Available date | 2019-04-16T12:50:41Z | |
| Document date | 2008 | |
| Citation | CAVALHER-MACHADO, S. C. et al. The allergic inflammatory reaction in neonatal streptozotocininduced diabetic rats: evidence of insulin resistance and microvascular dysfunction. Inflamm. res., v. 57, p. 535-541, 2008. | pt_BR |
| ISSN | 1023-3830 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32510 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Diabetes tipo 2 | pt_BR |
| Subject in Portuguese | Reação inflamatória alérgica | pt_BR |
| Subject in Portuguese | Permeabilidade vascular pulmonar | pt_BR |
| Title | The allergic inflammatory reaction in neonatal streptozotocininduced diabetic rats: evidence of insulin resistance and microvascular dysfunction | pt_BR |
| Type | Article | |
| DOI | 10.1007/s00011-008-8047-0 | |
| Abstract | Objective: To investigate the allergic reaction in neonatal streptozotocin (nSTZ)-induced diabetes mellitus. Material: Male newborn Wistar rats were made diabetic by the injection of streptozotocin (160mg/kg, i. p.) and used 8
weeks thereafter. Treatment: Animals were sensitized against ovalbumin (OA, 50µg and Al(OH)3, 5mg, s. c.) and challenged 14 or 21 days thereafter. Methods: OA-induced airway inflammation and OA-induced
pleurisy models were used to investigate leukocyte migration (total and differential leukocyte counts) and lung vascular permeability (Evans blue dye extravasation). Results: nSTZ-diabetic rats presented glucose intolerance and insulin resistance. Relative to controls, nSTZ rats exhibited a 30% to 50% reduction in lung vascular permeability. Leukocyte infiltration in both models of allergen-induced inflammation, and number of pleural mast cells did not differ between groups. Conclusions: Data suggest that the reduction of allergic inflammatory reactions in nSTZ rats is restricted to microvascular dysfunctions and associated, probably, with insulin resistance in lung microvascular endothelium. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina.Instituto do Coração. Divisão de Pesquisa. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Farmacologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Maringá. Departamento de Farmacologia. Maringá, PR, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Farmacologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Imunologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Farmacologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina.Instituto do Coração. Divisão de Pesquisa. São Paulo, SP, Brasil. | pt_BR |
| Subject | Type 2 diabetes | pt_BR |
| Subject | Allergic inflammatory reaction | pt_BR |
| Subject | Lung vascular permeability | pt_BR |
| e-ISSN | 1420-908X | |
| Embargo date | 2022-01-01 | |
