| Author | Fischer, Juliana de Saldanha da Gama | |
| Author | Carvalho, Paulo Costa | |
| Author | Ferreira, Ana Gisele da Costa Neves | |
| Author | Fonseca, Clovis Orlando da | |
| Author | Perales, Jonas | |
| Author | Carvalho, Maria da Glória da Costa | |
| Author | Domont, Gilberto Barbosa | |
| Access date | 2019-04-16T13:49:52Z | |
| Available date | 2019-04-16T13:49:52Z | |
| Document date | 2008 | |
| Citation | FISCHER, Juliana de Saldanha da Gama et al. Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. Journal of Experimental Therapeutics and Oncology, v. 7, p. 285-290, 2008. | pt_BR |
| ISSN | 1359-4117 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32515 | |
| Language | eng | pt_BR |
| Publisher | Old City Publishing | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Glioblastoma multiforme | pt_BR |
| Subject in Portuguese | Álcool Perillyl | pt_BR |
| Subject in Portuguese | Câncer | pt_BR |
| Subject in Portuguese | Proteômica | pt_BR |
| Subject in Portuguese | Biomarcadores | pt_BR |
| Title | Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol | pt_BR |
| Type | Article | |
| Abstract | Perillyl alcohol (POH) is a naturally occurring monoterpene
with antiangiogenic and anti-tumoral properties.
This chemotherapeutic agent has proven effectiveness
in several clinical trials, including an ongoing phase I,
comprising patients with recurrent glioblastoma multiform
(GBM) under treatment with POH by intranasal
administration. Proteomics offers tools to distinguish
states of biological systems according to protein expression
differences and therefore, can be used to gain pathological
insights and to search for disease follow-up
biomarkers- In this work, a differential gel electrophoresis
(DIGE) proteomic approach was used to search for
plasma proteins that correlated with the disease progression
in 10 of these patients. Our results pointed antithrombin
(down) and fibrinogen (up) regulated after a
four months treatment deserving to be further verified
as prognostic markers for this treatment. Possible links
between tumor progression and anti-thrombin expression
level are also discussed. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Engenharia de Sistemas e Ciência da Computação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Hospital Universitário Antonio Pedro. Serviço de Neurocirurgia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Departamento de Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Glioblastoma multiform | pt_BR |
| Subject | Perillyl alcohol | pt_BR |
| Subject | Cancer | pt_BR |
| Subject | DIGE | pt_BR |
| Subject | Proteomics | pt_BR |
| Subject | Biomarkers | pt_BR |
| DeCS | Eletroforese em Gel Diferencial Bidimensional | pt_BR |
| e-ISSN | 1533-869X | |
