| Author | Lopes, Mariana Carneiro | |
| Author | Amadeu, Thaís Porto | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Costa, Claudia Henrique | |
| Author | Rodrigues, Luciana Silva | |
| Author | Bessa, Elisabeth Jauhar Cardoso | |
| Author | Bruno, Leonardo Palermo | |
| Author | Lopes, Agnaldo José | |
| Author | Rufino, Rogerio | |
| Access date | 2019-04-18T01:02:34Z | |
| Available date | 2019-04-18T01:02:34Z | |
| Document date | 2019 | |
| Citation | LOPES, Mariana Carneiro et al. Identification of active sarcoidosis using chitotriosidase and angiotensin-converting enzyme. Lung, p. 1-8, Mar. 2019. | pt_BR |
| ISSN | 0341-2040 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32568 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | pt_BR |
| Title | Identification of active sarcoidosis using chitotriosidase and angiotensin-converting enzyme | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s00408-019-00219-2 | |
| Abstract | Purpose: Activity/remission differentiation is a great challenge in the follow-up and treatment of sarcoidosis patients. Angiotensin-converting enzyme (ACE) and high sensitivity C-reactive protein (hs-CRP) were proposed as sarcoidosis biomarkers. More recently, chitotriosidase (CHITO) has been described as a better alternative. This study has the aim to evaluate the association of CHITO activity, ACE, hs-CRP or a combination of these biomarkers and to construct a clinical algorithm to differentiate between sarcoidosis activity/remission status. Methods: Forty-six patients with either active sarcoidosis or sarcoidosis in remission and 21 healthy individuals were included. ACE, hs-CRP, and CHITO were evaluated in serum samples. Comparisons of the laboratory variable means among groups were performed by linear models. The cutoff points of the biomarkers for activity/remission differentiation were calculated using the Youden’s index. Biomarker cutoff points and decision tree classifier (DTC) performance were estimated by their leave-one-out cross-validation (LOOCV) accuracy (Acc), sensitivity (Se), and specificity (Sp). Results A 55% mean Se and a 100% mean Sp were found for CHITO, while an 88% Se and a 47% Sp were found for ACE, and a 66% Se and a 68% Sp for hs-CRP cutoff points for activity/remission differentiation. The DTC algorithm with CHITO, hs-CRP, and ACE information had an LOOCV mean Acc of 82%, Se of 78%, and Sp of 89% for sarcoidosis activity/remission differentiation. Conclusions: The algorithm involving CHITO, hs-CRP, and ACE could be a suitable strategy for differentiation between sarcoidosis activity/remission status. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Pulmonology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | Sarcoidosis | pt_BR |
| Subject | Activity | pt_BR |
| Subject | Biomarkers | pt_BR |
| Subject | Chitotriosidase | pt_BR |
| Subject | Angiotensin-converting enzyme | pt_BR |
| e-ISSN | 1432-1750 | |
| Embargo date | 2020-04-15 | |
