| Author | Gomes, Marilia de Brito | |
| Author | Cobas, Roberta Arnold | |
| Author | Nunes, Edson | |
| Author | Nery, Michele | |
| Author | Faria Neto, Hugo Caire C. | |
| Author | Tibiriçá, Eduardo | |
| Access date | 2019-04-18T13:30:33Z | |
| Available date | 2019-04-18T13:30:33Z | |
| Document date | 2008 | |
| Citation | GOMES, Marilia de Brito et al. Serum platelet-activating factor acetylhydrolase activity: A novel potential inflammatory marker in type 1 diabetes. Prostaglandins & other Lipid Mediators, v. 87, p. 42-46, July 2008. | pt_BR |
| ISSN | 1098-8823 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32586 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Diabetes Tipo 1 | pt_BR |
| Subject in Portuguese | Marcadores Inflamatórios | pt_BR |
| Subject in Portuguese | Complicações crônicas | pt_BR |
| Subject in Portuguese | Atividade da acetil-hidrolase do fator ativador de plaquetas | pt_BR |
| Title | Serum platelet-activating factor acetylhydrolase activity: A novel potential inflammatory marker in type 1 diabetes | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.prostaglandins.2008.07.001 | |
| Abstract | Plasma activity of the platelet-activating factor acetylhydrolase (PAF-AH) plays an important role in
inflammation and atherosclerotic process in chronic diseases. We aimed to evaluate the levels of PAFAH
activity and their association with the metabolic profile and chronic complications in patients
with type 1 diabetes. The study included 118 outpatients (54 males) aged 27.1±11.3 years with disease
duration of 12.3±8.5 years with (n = 38) or without (n = 80) diabetes complications and 96 control
subjects (48 males) matched for age, gender, body mass index and smoking habits. The serum levels
of PAF-AH activity were higher in patients either with or without chronic complications (16±5.3 and
14±5.4 nmol/(min mL), respectively) than in controls (13±5.1 nmol/(min mL), P = 0.02). In the total population,
PAF-AH activity was correlated with age, HDL-cholesterol, total cholesterol and LDL-cholesterol.
In patients, PAF-AH activity was correlated with age, HbA1c, uric acid, HDL-cholesterol, cholesterol,
LDL-cholesterol, cholesterol/HDL-cholesterol ratio and the LDL-cholesterol/HDL-cholesterol ratio. It is
concluded that PAF-AH plasma activity could be a novel candidate for low-grade inflammatory marker in
patients with type 1 diabetes. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Medicina. Unidade de Diabete. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Medicina. Unidade de Diabete. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Medicina. Unidade de Diabete. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Medicina. Unidade de Diabete. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Platelet-activating factor acetylhydrolase activity | pt_BR |
| Subject | Diabetes type 1 | pt_BR |
| Subject | Chronic complications | pt_BR |
| Subject | Inflammatory markers | pt_BR |
| Embargo date | 2022-01-01 | |
