| Author | Sabino, Cleto Lorena | |
| Author | Oleto, Aline de Freitas | |
| Author | Sousa, L. P. | |
| Author | Lopes, Tatiane de Oliveira Barreto | |
| Author | Cruz, Jader dos Santos | |
| Author | Penaforte, Cláudia Lopes | |
| Author | Magalhães, José Carlos | |
| Author | Souza, Franco Junia | |
| Author | Pinto, Kelerson Mauro Castro | |
| Author | Campi, Azevedo Ana Carolina | |
| Author | Vieira, Etel Rocha | |
| Access date | 2019-04-23T12:32:14Z | |
| Available date | 2019-04-23T12:32:14Z | |
| Document date | 2011 | |
| Citation | SABINO, Cleto Lorena et al. Plasma cytokine response, lipid peroxidation and NF-kB activation in skeletal muscle following maximum progressive swimming. Brazilian Journal of Medical and Biological Research, v. 44, n. 6, p. 546-552, 2011. | pt_BR |
| ISSN | 0100-879X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32677 | |
| Language | eng | pt_BR |
| Publisher | Associação Brasileira de Divulgação Científica | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Natação | pt_BR |
| Subject in Portuguese | NF-κB | pt_BR |
| Subject in Portuguese | Interleukin-6 | pt_BR |
| Subject in Portuguese | Interleukin-10 | pt_BR |
| Subject in Portuguese | Espécies reativas ao ácido tiobarbitúrico | pt_BR |
| Subject in Portuguese | citocinas | pt_BR |
| Title | Plasma cytokine response, lipid peroxidation and NF-kB activation in skeletal muscle following maximum progressive swimming | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0100-879X2011007500050 | |
| Abstract | Our objective was to determine lipid peroxidation and nuclear factor-κB (NF-κB) activation in skeletal muscle and the plasma cytokine profile following maximum progressive swimming. Adult male Swiss mice (N = 15) adapted to the aquatic environment were randomly divided into three groups: immediately after exercise (EX1), 3 h after exercise (EX2) and control. Animals from the exercising groups swam until exhaustion, with an initial workload of 2% of body mass attached to the tail. Control mice did not perform any exercise but were kept immersed in water for 20 min. Maximum swimming led to reactive oxygen species (ROS) generation in skeletal muscle, as indicated by increased thiobarbituric acid reactive species (TBARS) levels (4062.67 ± 1487.10 vs 19,072.48 ± 8738.16 nmol malondi - aldehyde (MDA)/mg protein, control vs EX1). Exercise also promoted NF-κB activation in soleus muscle. Cytokine secretion following exercise was marked by increased plasma interleukin-6 (IL-6) levels 3 h post-exercise (P < 0.05). Interleukin-10 (IL-10) levels were reduced following exercise and remained reduced 3 h post-exercise (P < 0.05). Plasma levels of other cytokines investigated, monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin-12 (IL-12), were not altered by exercise. The present findings showed that maximum swimming, as well as other exercise models, led to lipid peroxidation and NF-κB activation in skeletal muscle and increased plasma IL-6 levels. The plasma cytokine response was also marked by reduced IL-10 levels. These results were attributed to exercise type and intensity. | pt_BR |
| Affilliation | Centro Universitário de Belo Horizonte. Departamento de Ciências Biológicas, Ambientais e da Saúde. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Centro Universitário de Belo Horizonte. Departamento de Ciências Biológicas, Ambientais e da Saúde. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Colégio Técnico. Setor de Patologia Clínica. Departamento de Patologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Centro Universitário de Belo Horizonte. Departamento de Ciências Biológicas, Ambientais e da Saúde. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Centro Universitário de Belo Horizonte. Departamento de Ciências Biológicas, Ambientais e da Saúde. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São João Del Rey. Ouro Branco, MG, Brasil. | pt_BR |
| Affilliation | Centro Universitário de Belo Horizonte. Departamento de Ciências Biológicas, Ambientais e da Saúde. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Centro Desportivo da Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil. | pt_BR |
| Affilliation | Centro Universitário de Belo Horizonte. Departamento de Ciências Biológicas, Ambientais e da Saúde. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Departamento de Ciências Básicas. Diamantina, MG, Brasil. | pt_BR |
| Subject | Swimming | pt_BR |
| Subject | NF-κB | pt_BR |
| Subject | Interleukin-6 | pt_BR |
| Subject | Interleukin-10 | pt_BR |
| Subject | Thiobarbituric acid reactive species | pt_BR |
| Subject | Cytokine | pt_BR |
