| Author | Azevedo, Ana Carolina Campi | |
| Author | Gazzinelli, Giovanni | |
| Author | Bottazzi, Maria Elena | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Caldas, Iramaya Rodrigues | |
| Access date | 2019-04-23T12:53:33Z | |
| Available date | 2019-04-23T12:53:33Z | |
| Document date | 2007 | |
| Citation | AZEVEDO, Ana Carolina Campi et al. In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens. Microbes and Infection, v. 9, n. 12-13, p. 1493-1499, 2007. | pt_BR |
| ISSN | 1769-714X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32678 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Esquistossomosse | pt_BR |
| Subject in Portuguese | citometria de fluxo | pt_BR |
| Subject in Portuguese | ciclo celular | pt_BR |
| Subject in Portuguese | proliferação | pt_BR |
| Title | In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.micinf.2007.08.004 | |
| Abstract | Infection with Schistosoma mansoni induces a wide range of effects on the immune responses of the host. In the present study we investigated the influence of soluble egg antigens (SEA) on the cell cycle of peripheral blood mononuclear cells (PBMC) from infected and non-infected individuals with S. mansoni resident in an endemic area and blood donors from non-endemic area. The cell cycle, the expression of activation markers and cyclin D+1,2,3 CD3+ frequency was assessed by flow cytometry. Stimulation of PBMC from infected patients with SEA resulted in a lower frequency of CD3+ T cells in S phase when compared with the non-infected group. In addition, infected patients presented a decrease of activation marker expression (CD69+, HLA-DR+ and CD28− on CD4+ cells and CD25+, HLA-DR+ on CD8+ cells). A reduced frequency was observed of cyclin D1,2,3 expression in SEA-stimulated T cells from infected individuals when compared with those from the non-infected group. The decreased expression of activation markers and frequency of cyclin D1,2,3 in T cells may result in arrest of T cells in the G0/G1 phase of the cell cycle, thus explaining the down-regulation observed in chronic schistosomiasis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Santa Casa de Belo Horizonte. Nucleo de Pós-graduação. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Department of Microbiology and Tropical Medicine. The George Washington University. Medical Center. Washington, DC, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Flow cytometry | pt_BR |
| Subject | Cell cycle | pt_BR |
| Subject | Proliferation | pt_BR |
| Subject | Cyclin D1,2,3 | pt_BR |
| Embargo date | 2025-01-01 | |
