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| Autor | Gomes, S. A. | |
| Autor | Castro, L. de | |
| Autor | Niel, C. | |
| Autor | Santos, E. A. | |
| Fecha de acceso | 2019-04-30T13:00:13Z | |
| Fecha de disponibilización | 2019-04-30T13:00:13Z | |
| Fecha de publicación | 2004 | |
| Referencia | GOMES, S. A. et al. Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS. Journal of Infection, v. 48, p. 102-108, 2004. | pt_BR |
| ISSN | 0163-4453 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32872 | |
| Descripción | Liane de Castro. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Derechos de autor | open access | pt_BR |
| Título | Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1016/S0163-4453(03)00126-9 | |
| Resumen en Inglés | Objective. To study the genomic variations of a hepatitis B virus (HBV) isolate in a patient coinfected with human immunodeficiency virus type 1 (HIV-1) who developed severe hepatitis and died of AIDS. Methods. Two blood samples were collected, the first one during the asymptomatic phase of HIV-1 infection, and the other, 3 years later, few months before the death of the patient. Both samples were HBsAg and anti-HBe positive. Pre-S/S and precore-core genome regions were PCR amplified and analyzed. Results. The HBV isolate belonged to genotype F, cluster IV. A number of unique amino acid substitutions were found in the surface antigen gene and the overlapping polymerase coding region of HBV genomes derived from both samples. However, these substitutions reflected natural variations rather than mutations of clinical significance. The precore stop codon mutation A1896 was present in both genomes. Furthermore, the HBV genome derived from the second, but not first sample, showed two out-of-frame core interval deletions, one and 103 nucleotides in length, respectively. Conclusions. This is the first report of an HBV isolate from genotype F with core internal deletions. Our results suggest an association between specific core mutations and the severe hepatitis developed by the patient. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Sem afiliação. | pt_BR |
| Afiliación | Sem afiliação. | pt_BR |
| Afiliación | Sem afiliação. | pt_BR |
| Palavras clave en Inglês | AIDS | pt_BR |
| Palavras clave en Inglês | Core internal deletion | pt_BR |
| Palavras clave en Inglês | Genotype F | pt_BR |
| Palavras clave en Inglês | Hepatitis B virus | pt_BR |
| Palavras clave en Inglês | Precore stop mutation | pt_BR |
| Fecha de embargo | 2020-04-30 |
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