Mostrar el registro sencillo del ítem
| Autor | Castro, Liane de | |
| Autor | Niel, C. | |
| Autor | Gomes, S. A. | |
| Fecha de acceso | 2019-04-30T14:46:50Z | |
| Fecha de disponibilización | 2019-04-30T14:46:50Z | |
| Fecha de publicación | 2001 | |
| Referencia | CASTRO, Liane de; NIEL, Christian; GOMES, Selma A. Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers. BMC Microbiology, v. 1 p. 1-9, 2001. | pt_BR |
| ISSN | 1471-2180 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32883 | |
| Descripción | Liane de Castro. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | BMC | pt_BR |
| Derechos de autor | open access | |
| Título | Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers | pt_BR |
| Tipo del documento | Article | |
| DOI | 10.1186/1471-2180-1-10 | |
| Resumen en Inglés | Background: Mutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions 1762-1764 in the core promoter, and the precore stop codon mutation G to A at nt 1896, can often explain the anti-HBe phenotype in chronic carriers. However, the A1896 mutation is restricted to HBV isolates that have T at nt 1858. The double substitution at positions 1762-1764 has been described to occur preferentially in patients infected with strains showing C instead of T at nt 1858. Results: HBV DNAs from 29 anti-HBe Brazilian samples were characterized by nucleotide sequencing of PCR products from precore region. Among them, 18 isolates presented C at nt 1858 (mostly genotype A strains). The 11 remaining isolates (genotypes D and F) had T1858. The stop codon mutation at nt 1896 was found in seven isolates (24% of the total and 63% of the isolates that had T1858). The frequency of the double substitution at positions 1762-1764 was surprisingly low (20%) among C1858 isolates. An association between A1896 and TGA 1762-1764 mutations was observed among genotype D isolates: these showed either none of the two mutations or both. Furthermore, strains mutated at positions 1896 and/or 1762-1764 also presented an elevated number of other, less common substitutions in the core promoter and precore regions. Conclusions: The data reported here are not in accordance with some reports from other parts of the world. In half of the isolates, none of the mutations previously described could explain the anti-HBe phenotype. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras clave en Inglês | Hepatitis B virus | pt_BR |
| Palavras clave en Inglês | Mutations in the core promoter and precore | pt_BR |
| Palavras clave en Inglês | Anti-HBe positive Brazilian carriers | pt_BR |
| e-ISSN | 1471-2180 |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
INI - Artigos de Periódicos [3646]
-
IOC - Artigos de Periódicos [12978]