| Author | Salles, Gil F. | |
| Author | Xavier, Sergio S. | |
| Author | Sousa, Andrea S. | |
| Author | Hasslocher-Moreno, Alejandro Marcel | |
| Author | Cardoso, Claudia R. L. | |
| Access date | 2019-05-02T14:56:43Z | |
| Available date | 2019-05-02T14:56:43Z | |
| Document date | 2004 | |
| Citation | SALLES, Gil F. et al. T-wave axis deviation as an independent predictor of mortality in chronic Chagas’ disease. American Journal of Cardiology, v. 93, p. 1136-1140, May 1 2004. | pt_BR |
| ISSN | 0002-9149 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32912 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | T-wave axis deviation as an independent predictor of mortality in chronic Chagas' disease | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.amjcard.2004.01.040 | |
| Abstract | The T-wave axis shift has been reported to represent a general marker of ventricular repolarization abnormalities and a potential indicator of increased risk for cardiovascular mortality. We assessed the prognostic importance of the T-wave axis deviation for mortality rate in patients with chronic Chagas’ disease. In a long-term follow-up prospective study, 738 adult outpatients in the chronic phase of Chagas’ disease were enrolled. The frontal plane T-wave axis was estimated from 12-lead electrocardiograms obtained on admission and categorized as normal (15° to 75°), borderline (75° to 105° or 15° to 15°), and abnormal (>105° or < 15°). Clinical and radiologic data, 2-dimensional echocardiographic data, and other electrocardiographic data were also recorded. Primary end points were all-cause, those related to Chagas’ disease, and sudden cardiac deaths. Statistical analyses included Kaplan-Meier estimation of
survival curves and multivariate Cox’s proportional hazards models. During a follow-up of 58 39 months, 62
patients died, 54 from causes related to Chagas’ disease and 40 due to sudden cardiac death. Kaplan-Meier
survival curves showed that the 3 categories of T axis had significantly different prognoses. Multivariate Cox’s survival analysis demonstrated that an abnormal T axis increases the risk of death threefold and sudden death nearly sixfold after adjustment for other covariates, including left ventricular systolic function and other electrocardiographic abnormalities. Borderline T-wave axis also indicated a worse prognosis, particularly in the subgroup of patients with abnormal baseline electrocardiograms. These results indicate that T-wave axis deviation is an easily quantified, strong, and independent mortality risk predictor in patients with chronic Chagas’ disease. | pt_BR |
| Affilliation | Federal University of Rio de Janeiro. Medical Faculty. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Federal University of Rio de Janeiro. Medical Faculty. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Federal University of Rio de Janeiro. Medical Faculty. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Federal University of Rio de Janeiro. Medical Faculty. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Chronic Chagas’ disease | pt_BR |
| Subject | T-Wave axis deviation | pt_BR |
| Subject | Predictor of mortality | pt_BR |
| Subject | Chagas Disease | pt_BR |
| e-ISSN | 1879-1913 | |
| Embargo date | 2028-12-31 | |
