| Author | Teles, Amanda Mara | |
| Author | Rosa, Taynan Dulce da Silva | |
| Author | Mouchrek, Adenilde Nascimento | |
| Author | Silva, Ana Lucia Abreu | |
| Author | Calabrese, Kátia da Silva | |
| Author | Souza, Fernando Almeida | |
| Access date | 2019-05-02T16:03:06Z | |
| Available date | 2019-05-02T16:03:06Z | |
| Document date | 2019 | |
| Citation | TELES, Amanda Mara et al. Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 2421965, 12p, 2019. | pt_BR |
| ISSN | 1741-427X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32916 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cinnamomum zeylanicum | pt_BR |
| Subject in Portuguese | Origanum vulgare | pt_BR |
| Subject in Portuguese | Curcuma longa | pt_BR |
| Subject in Portuguese | Óleos essenciais | pt_BR |
| Subject in Portuguese | Composição química | pt_BR |
| Subject in Portuguese | Atividade Antileishmanial | pt_BR |
| Subject in Portuguese | Atividade antimicrobiana | pt_BR |
| Title | Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity | pt_BR |
| Type | Article | |
| DOI | 10.1155/2019/2421695 | |
| Abstract | The resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils. Chemical analysis was performed by gas chromatography-mass spectrometry. Antimicrobial activity was performed by disk diffusion and minimum inhibitory concentration (MIC) test. Antileishmanial activity was performed against antipromastigote and intracellular amastigote of Leishmania amazonensis. Cytotoxic and nitrite production were realized in BALB/c peritoneal macrophages. The major compounds of the essential oils were cinnamic aldehyde (46.30%) in C. zeylanicum, cis-p-menth-2-en-1-ol (33.88%) and linalyl acetate (13.90%) in O. vulgare, and turmerone (55.43%) in C. longa. The MIC showed significant antimicrobial activity of C. longa essential oil against S. aureus (83.3 ± 14.43 µg/mL). Antipromastigote activity showed IC50 values >500 µg/mL to C. zeylanicum, 308.4 ± 1.402 µg/mL to O. vulgare, and 405.5 ± 1.119 µg/mL to C. longa essential oil. Activity against intracellular amastigote of L. amazonensis showed IC50 of 63.3 ± 1.369 µg/mL and cytotoxic was not observed, resulting in selectivity index higher than 15.79 to parasite. C. longa essential oil decreased nitrite production in peritoneal macrophages, but not in Leishmania-infected cells. The chemical composition of the three essential oils is directly associated to its potential biological action, as the antimicrobial activity. C. longa presented a potent antileishmanial activity against promastigote and intracellular amastigote of L. amazonensis, although this activity is not linked to nitric oxide, since C. longa essential oil inhibits its production. | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luís, MA, Brasil / Rede Nordeste de Biotecnologia. Ponto Focal Maranhão. São Luís, MA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Mestrado em Ciência Animal. São Luís, MA, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luís, MA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Mestrado em Ciência Animal. São Luís, MA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Mestrado em Ciência Animal. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Cinnamomum zeylanicum | pt_BR |
| Subject | Origanum vulgare | pt_BR |
| Subject | Curcuma longa | pt_BR |
| Subject | Essential Oils | pt_BR |
| Subject | Antileishmanial Activity | pt_BR |
| Subject | Chemical Composition | pt_BR |
| Subject | Antimicrobial Activity | pt_BR |
| e-ISSN | 1741-4288 | |
