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| Autor | Sampaio, Aletheia Soares | |
| Autor | Vasconcelos, Ana Lúcia Ribeiro de | |
| Autor | Morais, Clarice Neuenschwander Lins de | |
| Autor | Diniz, George Tadeu Nunes | |
| Autor | Figueiredo, Anna Lígia de Castro | |
| Autor | Montenegro, Sílvia Maria Lucena | |
| Fecha de acceso | 2019-05-14T16:07:10Z | |
| Fecha de disponibilización | 2019-05-14T16:07:10Z | |
| Fecha de publicación | 2018 | |
| Referencia | SAMPAIO, Aletheia Soares et al. Social Conditions and Immune Response in Human Immunodeficiency Virus-Seropositive Pregnant Women: A Cross-Sectional Study in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 21–29, fev. 2018. | pt_BR |
| ISSN | 1678-9849 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33067 | |
| Promoción | Strategic Program to Support Research in Health (PAPES VI), National Council for Technological and Scientific Development, Oswaldo Cruz Foundation, 407.650/2012-1. | pt_BR |
| Idioma | eng | pt_BR |
| Derechos de autor | open access | pt_BR |
| Título | Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1590/0037-8682-0107-2017 | |
| Resumen en Inglés | The functioning of the immune system during pregnancy is altered in both human immunodeficiency virus (HIV)-infected and uninfected women. Unfavorable socioeconomic conditions have been indicative of higher morbidity and mortality and worsening of the immune system. The aim of this study was to correlate social status with levels of interleukin (IL)-10 (non-inflammatory) and interferon-gamma (IFN-γ; inflammatory) cytokines. METHODS: A cross-sectional study was conducted with three groups of women: 33 pregnant HIV-infected (G1); 40 non-pregnant, HIV-infected (G2); and 35 pregnant, HIV-uninfected. To measure the social status, a compound indicator called the social status index (SSI), was established using sociodemographic variables (i.e., education level, housing conditions, per capita income, and habitation and sanitary conditions). RESULTS: The HIV-infected women had a higher proportion of unfavorable SSI (73% and 75% of G1 and G2, respectively). There were significantly lower IL-10 levels in the G1 group with both unfavorable and favorable SSI than in the other groups. No significant difference in IFN-γ levels was observed among groups. However, the G1 group had higher IFN-γ values among both favorable and unfavorable SSI groups. CONCLUSIONS: Higher rates of unfavorable conditions, including lower education levels, IL-10 levels, and a trend for higher IFN-γ levels, were identified among HIV-infected women, pregnant and non-pregnant. These factors may interfere in health care and lead to poor outcomes during pregnancy. Therefore, we suggest that health policies could be created to specifically address these factors in this population. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil / Universidade de Pernambuco. Centro Integrado de Saúde Amaury de Medeiros. Serviço de Atendimento Especializado em HIV/AIDS. Recife, PE, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil. | pt_BR |
| Afiliación | Universidade de Pernambuco. Centro Integrado de Saúde Amaury de Medeiros. Serviço de Atendimento Especializado em HIV/AIDS. Recife, PE, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia e Imunopatologia Celular. Recife, PE, Brasil. | pt_BR |
| Palavras clave en Inglês | Acquired immunodeficiency syndrome | pt_BR |
| Palavras clave en Inglês | Pregnancy | pt_BR |
| Palavras clave en Inglês | Poverty | pt_BR |
| Palavras clave en Inglês | Interleukin-10 | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Estudos Transversais | pt_BR |
| DeCS | Fêmea | pt_BR |
| DeCS | Infecções por HIV / sangue | pt_BR |
| DeCS | Infecções por HIV / imunologia | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Interferon gama / sangue | pt_BR |
| DeCS | Interferon gama / imunologia | pt_BR |
| DeCS | Interleucina-10 / sangue | pt_BR |
| DeCS | Interleucina-10 / imunologia | pt_BR |
| DeCS | Gravidez | pt_BR |
| DeCS | Complicações na Gravidez Infecciosa / sangue | pt_BR |
| DeCS | Complicações na Gravidez Infecciosa / imunologia | pt_BR |
| DeCS | Complicações na Gravidez Infecciosa / virologia | pt_BR |
| DeCS | Condições sociais | pt_BR |
| DeCS | Fatores Socioeconômicos | pt_BR |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza |
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