| Author | Santos, Laise Aline Martins dos | |
| Author | Rodrigues, Gabriel Barros | |
| Author | Mota, Fernanda Virgínia Barreto | |
| Author | França, Maria Eduarda Rocha de | |
| Author | Barbosa, Karla Patrícia de Souza | |
| Author | Oliveira, Wilma Helena de | |
| Author | Rocha, Sura Wanessa Santos | |
| Author | Lós, Deniele Bezerra | |
| Author | Silva, Amanda Karolina Soares | |
| Author | Silva, Teresinha Gonçalves da | |
| Author | Peixoto, Christina Alves | |
| Access date | 2019-05-14T17:23:33Z | |
| Available date | 2019-05-14T17:23:33Z | |
| Document date | 2018 | |
| Citation | SANTOS, Laise Aline Martins dos et al. New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation. International Immunopharmacology, v. 57, p. 91-101, Apr. 2018. | pt_BR |
| ISSN | 1878-1705 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33073 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (the Brazilian NationalCouncil for Scientific and Technological Development) (CNPq;#301777/2012-8). | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.intimp.2018.02.011 | |
| Abstract | Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as potential drugs for the treatment of ALI and ARDS due to their anti-inflammatory efficacy. The present study aims to evaluate the potential anti-inflammatory effects of new TZDs derivatives, LPSF/GQ-2 and LPSF/RA-4, on ALI induced by LPS. BALB/c mice were divided into five groups: 1) Control; 2) LPS intranasal 25 μg; 3) LPSF/GQ-2 30 mg/kg + LPS; 4) LPSF/RA-4 20 mg/kg + LPS; and 5) DEXA 1 mg/Kg + LPS. BALF analyses revealed that LPSF/GQ-2 and LPSF/RA-4 reduced NO levels in BALF and inflammatory cell infiltration induced by LPS. MPO levels were also reduced by the LPSF/GQ-2 and LPSF/RA-4 pre-treatments. In contrast, histopathological analyses showed better tissue protection with LPSF/GQ-2 than DEXA and LPSF/RA-4 groups. Similarly, LPSF/GQ-2 reduced inflammatory markers (IL-1, iNOS, TNFα, IL-1β, IL-6) better than LPSF/RA-4. The LPSF/GQ-2 anti-inflammatory action could be attributed to the inhibition of NFκB, ERK, p38, and PARP pathways. In contrast, LPSF/RA-4 had no effect on the expression of p38, JNK, NFκB. The present study indicates that LPSF/GQ-2 presents a potential therapeutic role as an anti-inflammatory drug for ALI. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Programa de Pós-graduação em Biocîencias e Biotecnologia em Saúde. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade do estado de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação em Biotecnologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Programa de Pós-Graduação. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Instituto de Ciências e Tecnologia em Neuroimunomodulação. Recife, PE, Brasil. | pt_BR |
| Subject | Acute lung injury | pt_BR |
| Subject | MAPKs | pt_BR |
| Subject | NFκB | pt_BR |
| Subject | Thiazolidinediones (TDZs) | pt_BR |
| DeCS | Lesão Pulmonar Aguda / quimioterapia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Anti-Inflamatórios / uso terapêutico | pt_BR |
| DeCS | Citocinas / metabolismo | pt_BR |
| DeCS | Modelos de Doença Animal | pt_BR |
| DeCS | MAP Quinases Reguladas por Sinal Extracelular / metabolismo | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Mediadores da Inflamação / metabolismo | pt_BR |
| DeCS | Lipopolissacarídeos / imunologia | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | NF-kappa B / metabolismo | pt_BR |
| DeCS | Receptores / agonistas ativados por proliferadores de peroxissoma | pt_BR |
| DeCS | Pneumonia / quimioterapia | pt_BR |
| DeCS | Síndrome do Desconforto Respiratório do Adulto / quimioterapia | pt_BR |
| DeCS | Transdução de Sinal | pt_BR |
| DeCS | Tiazolidinedionas / uso terapêutico | pt_BR |
| Embargo date | 2050-01-01 | |
