| Author | Carvalho, C. M. E. | |
| Author | Andrade, M. C. R. | |
| Author | Xavier, S. S. | |
| Author | Mangia, R. H. R. | |
| Author | Britto, C. C. | |
| Author | Jansen, A. M. | |
| Author | Fernandes, O. | |
| Author | Vieira, J. L. | |
| Author | Almeida, M. D. B. | |
| Access date | 2019-05-23T14:19:49Z | |
| Available date | 2019-05-23T14:19:49Z | |
| Document date | 2003 | |
| Citation | CARVALHO, Cristiano Marcelo Espinola et al. Chronic Chagas' disease in rhesus monkeys (Macaca mulatta): evaluation of parasitemia, serology, electrocardiography, echocardiography, and radiology. American Journal of Tropical Medicine and Hygiene, v. 68, n. 6, p. 683-691, 2003. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33195 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | |
| Title | Chronic Chagas' disease in rhesus monkeys (Macaca mulatta): evaluation of parasitemia, serology, electrocardiography, echocardiography, and radiology | pt_BR |
| Type | Article | |
| Abstract | Severe chronic damage to the heart and gastrointestinal tract in patients with Chagas’ disease are often
observed 10-20 years after the acute phase. The course of long-lasting infection with the Colombian strain of Trypanosoma cruzi was studied in seven rhesus monkeys infected for 15–19 years. Subpatent parasitemia was detected in all studied animals, using hemoculture (two of seven), artificial xenodiagnosis (three of seven), and a polymerase chain reaction PCR (six of six). High titers of specific IgG antibody to T. cruzi persisted throughout the chronic phase of infection. Abnormal electrocardiographic (three of six) and echocardiographic (one of six) patterns detected in the T. cruzi-infected monkeys were possibly related to parasite-triggered myocardial damage. The results suggest that rhesus monkeys experimentally infected with T. cruzi, besides reproducing the acute phase of Chagas’ disease, also develop chronic chagasic cardiomyopathy. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Criação de Animais de Laboratório. Departamento de Primatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Especialidades Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Chagas' disease | pt_BR |
| Subject | Rhesus monkeys | pt_BR |
| Subject | Parasitemia | pt_BR |
| Subject | Serology | pt_BR |
| Subject | Electrocardiography | pt_BR |
| Subject | Echocardiography | pt_BR |
| Subject | Radiology | pt_BR |
| e-ISSN | 1476-1645 | |
| Embargo date | 2020-05-23 | |
