| Author | Azeredo, Elzinandes L. | |
| Author | Zagne, Sonia M. O. | |
| Author | Alvarenga, Allan R. | |
| Author | Nogueira, Rita Maria R. | |
| Author | Kubelka, Claire F. | |
| Author | Pinto, Luzia M. de Oliveira | |
| Access date | 2019-06-04T13:23:56Z | |
| Available date | 2019-06-04T13:23:56Z | |
| Document date | 2006 | |
| Citation | AZEREDO, Elzinandes L. et al. Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 437-449, June 2006. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33356 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Ativação de linfócitos de pacientes | pt_BR |
| Title | Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762006000400016 | pt_BR |
| Abstract | The immune mechanisms involved in dengue fever and dengue hemorrhagic/dengue shock syndrome are not well
understood. The ex vivo activation status of immune cells during the dengue disease in patients was examined. CD4
and CD8 T cells were reduced during the acute phase. Interestingly, CD8 T cells co-expressing activation marker
HLA-DR, Q, P, and cytolytic granule protein-Tia-1 were significantly higher in dengue patients than in controls.
Detection of adhesion molecules indicated that in dengue patients the majority of T cells (CD4 and CD8) express the
activation/memory phenotype, characterized as CD44HIGH and lack the expression of the naïve cell marker, CD62LLOW.
Also, the levels of T cells co-expressing ICAM-1 (CD54), VLA-4, and LFA-1 (CD11a) were significantly increased.
CD8 T lymphocytes expressed predominantly low levels of anti-apoptotic molecule Bcl-2 in the acute phase, possibly
leading to the exhibition of a phenotype of activated/effector cells. Circulating levels of IL-18, TGF-β1 and
sICAM-1 were significantly elevated in dengue patients. Early activation events occur during acute dengue infection
which might contribute to viral clearance. Differences in expression of adhesion molecules among CD4 and
CD8 T cells might underlie the selective extravasation of these subsets from blood circulation into lymphoid organs
and/or tissues. In addition, activated CD8 T cells would be more susceptible to apoptosis as shown by the alteration
in Bcl-2 expression. Cytokines such as IL-18, TGF-β1, and sICAM-1 may be contributing by either stimulating or
suppressing the adaptative immune response, during dengue infection, thereby perhaps establishing a relationship
with disease severity. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Clínica Médica. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Dengue | pt_BR |
| Subject | Patients lymphocytes activation | pt_BR |
| e-ISSN | 1678-8060 | |
