| Author | Lima, Nadja M. F. | |
| Author | Correia, Clariane S. | |
| Author | Leon, Leonor L. | |
| Author | Machado, Gérzia M. C. | |
| Author | Madeira, Maria de Fátima | |
| Author | Santana, Antônio Euzébio G. | |
| Author | Goulart, Marília O. F. | |
| Access date | 2019-06-10T19:57:18Z | |
| Available date | 2019-06-10T19:57:18Z | |
| Document date | 2004 | |
| Citation | LIMA, Nadja M. F. et al. Antileishmanial activity of lapachol analogues. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 7, p. 757-761, Nov. 2004. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33447 | |
| Description | Maria de Fátima Madeira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Title | Antileishmanial activity of lapachol analogues | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762004000700017 | |
| Abstract | The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives
(potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis: L. amazonensis and L. braziliensis. All compounds presented significant activity, being isolapachol acetate the most active against promastigotes, with IC50/24h = 1.6 ± 0.0 µg/ml and 3.4 ± 0.5 µg/ml for, respectively, L. amazonensis and L. braziliensis. This compound was also assayed in vivo against L. amazonensis and showed to be active. Its toxicity in vitro was also established, and at concentration similar to the IC50, no toxicity was evidenced. In all experiments, pentamidine isethionate was used as a reference drug. The present results reinforce the potential use of substituted hydroxyquinones and derivatives as promising antileishmanial drugs and suggest a continuing study within this class of compounds. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Centro de Ciências Exatas e Naturais. Departamento de Química. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Centro de Ciências Exatas e Naturais. Departamento de Química. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Centro de Ciências Exatas e Naturais. Departamento de Química. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Centro de Ciências Exatas e Naturais. Departamento de Química. Maceió, AL, Brasil. | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | Leishmania braziliensis | pt_BR |
| Subject | Lapachol | pt_BR |
| Subject | Isolapachol | pt_BR |
| Subject | Antileishmanial activity | pt_BR |
| Subject | Naphthoquinones | pt_BR |
| e-ISSN | 1678-8060 | |
