| Author | Savino, Wilson | |
| Author | Moraes, Maria do Carmo Leite de | |
| Author | Barbosa, Suse Dayse Silva | |
| Author | Fonseca, Eliene Carvalho da | |
| Author | Almeida, Vinicius Cotta de | |
| Author | Hontebeyrie-Joscowicz, Mireille | |
| Access date | 2019-06-18T16:45:08Z | |
| Available date | 2019-06-18T16:45:08Z | |
| Document date | 1992 | |
| Citation | SAVINO, Wilson et al. Is the thymus a target organ in infetious diseases. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. V, p. 73-78, 1992. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33552 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Timo | pt_BR |
| Subject in Portuguese | Doenças infecciosas | pt_BR |
| Subject in Portuguese | Timócitos | pt_BR |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Subject in Portuguese | AIDS | pt_BR |
| Subject in Portuguese | Microambiente tímico | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Title | Is the thymus a target organ in infectious diseases? | pt_BR |
| Type | Article | |
| DOI | 10.1590/s0074-02761992000900010 | pt_BR |
| Abstract | The thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major and common feature observed in acute viral, bacterial and parasitic diseases, is a depletion of cortical thymocytes, mostly those bearing the CD4-CD8 double positive phenotype. This occurs simmultaneously to the relative enrichment in medullary CD4 or CD8 single positive cells, expressing high densities of the CD3 complex. Additionally we noticed a variety of changes in the thymic microenvironment (and particularly is epithelial component), comprising abnormal location of thymic epithelial cell subsets as well has a denser Ia-bearing cellular network. Moreover, the extracellular matrix network was altered with an intralobular increase of basement membrane proteins that positively correlated with the degree of thymocyte death. Lastly, anti-thymic cell antibodies were detected in both human and animal models of infectious diseases, and in some of them a phenomenon of molecular mimicry could be evidenced. Taken together, the data receiwed herein clearly show that the thymus should be regarded as a target in infectious diseases. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Institut Pasteur. Unité de Immunoparasitolgie. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Institut Pasteur. Unité de Immunoparasitolgie. Paris, France. | pt_BR |
| Subject | Thymus | pt_BR |
| Subject | Thymic microenvironment | pt_BR |
| Subject | Thymocites | pt_BR |
| Subject | Infectious diseases | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | AIDS | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
