| Author | Amolegbe, Saliu Alao | |
| Author | Hirano, Yui | |
| Author | Adebayo, Joseph Oluwatope | |
| Author | Ademowo, Olusegun George | |
| Author | Balogun, Elizabeth Abidemi | |
| Author | Obaleye, Joshua Ayoola | |
| Author | Krettli, Antoniana Ursine | |
| Author | Yu, Chengzhong | |
| Author | Hayami, Shinya | |
| Access date | 2019-06-19T18:25:04Z | |
| Available date | 2019-06-19T18:25:04Z | |
| Document date | 2018 | |
| Citation | AMOLEGBE, Saliu Alao et al. Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance. Scientific Reports, v. 8, 3078, 2018 | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33598 | |
| Language | eng | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Malaria | pt_BR |
| Subject in Portuguese | Plasmodium | pt_BR |
| Title | Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-018-21351-8 | |
| Abstract | The use of nanocarriers in drug delivery is a breakeven research and has received a clarion call in biomedicine globally. Herein, two newly nano-biomaterials: MCM-41 encapsulated quinine (MCM-41 ⊃ QN) (1) and 3-phenylpropyl silane functionalized MCM-41 loaded QN (pMCM-41 ⊃ QN) (2) were synthesized and well characterized. 1 and 2 along with our two already reported nano-antimalarial drugs (MCM-41 ⊃ ATS) (3) and 3-aminopropyl silane functionalized MCM-41 contained ATS (aMCM-41 ⊃ ATS) (4) were screened in vitro for their activity against P. falciparium W2 strain, cytotoxicity against BGM cells and in vivo for their activity against Plasmodium bergheiNK65. 1 has the highest antimalarial activity in vivo against P. berghei NK65, (ED50: < 0.0625 mg/kg body weight) and higher mean survival time compared to the other nano biomaterials or unencapsulated drugs at doses higher than 0.0625 mg/kg body weight. This encapsulation strategy of MCM-41 ⊃ QN (1) stands very useful and effective in delivering the drug to the target cells compared to other delivery systems and therefore, this encapsulated drug may be considered for rational drug design. | pt_BR |
| Affilliation | Federal University of Agriculture. College of Physical Sciences. Department of Chemistry. Abeokuta, Abeokuta, Nigeria/ Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan | pt_BR |
| Affilliation | Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan | pt_BR |
| Affilliation | University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria | pt_BR |
| Affilliation | University of Ibadan. College of Medicine University College Hospital. Institute for Advanced Medical Research and Training. Ibadan, Nigeria | pt_BR |
| Affilliation | University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria | pt_BR |
| Affilliation | University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Malaria. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | The University of Queensland. Australian Institute for Bioengineering and Nanotechnology. Queensland, QLD, Australia | pt_BR |
| Affilliation | Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan/ Kumamoto University. Institute of Pulsed Power Science. Kurokami, Chuo-ku, Kumamoto, Japan | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Plasmodium | pt_BR |
| Subject | nano-antimalaria drugs | pt_BR |
| Embargo date | 2022-01-01 | |
