| Author | Costa, Pedro Augusto Carvalho | |
| Author | Figueiredo, Maria Marta | |
| Author | Diniz, Suelen Queiroz | |
| Author | Marino, Ana Paula Maia Peixoto | |
| Author | Maloy, Kevin J | |
| Author | Carvalho, Andrea Teixeira de | |
| Author | Tada, Mauro Shugiro | |
| Author | Pereira, Dhelio Batista | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Antonelli, Lis Ribeiro do Valle | |
| Access date | 2019-06-19T19:19:34Z | |
| Available date | 2019-06-19T19:19:34Z | |
| Document date | 2018 | |
| Citation | COSTA, Pedro Augusto Carvalho et al. Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria. J Infect Dis., v. 218, n. 8, p. 1314-1323, 2018 | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33604 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Malaria | pt_BR |
| Subject in Portuguese | Plasmodium vivax | pt_BR |
| Title | Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria | pt_BR |
| Type | Article | |
| DOI | 10.1093/infdis/jiy296 | |
| Abstract | The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the induction of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen (CTLA-4) on Treg during malaria and to evaluate their function. We found that P. vivax infection triggered an increase in circulating Treg and their expression of CTLA-4 and PD-1. Functional analysis demonstrated that Treg from malaria patients had impaired suppressive ability and PD-1+Treg displayed lower levels of Foxp3 and Helios, but had higher frequencies of T-box transcription factor+ and interferon-gamma+ cells than PD-1-Treg. Thus malaria infection alters the function of circulating Treg by triggering increased expression of PD-1 on Treg that is associated with decreased regulatory function and increased proinflammatory characteristics | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Sir William Dunn School of Pathology. University of Oxford. United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Brazil | pt_BR |
| Affilliation | Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Embargo date | 2025-01-01 | |
