| Author | Araújo, Abelardo | |
| Author | Hall, William W. | |
| Access date | 2019-06-21T12:19:53Z | |
| Available date | 2019-06-21T12:19:53Z | |
| Document date | 2004 | |
| Citation | ARAUJO, Abelardo; HALL, William W. Human T-lymphotropic virus type II and neurological disease. Annals of Neurology, v. 56, n. 1, p. 10-19, July 2004. | pt_BR |
| ISSN | 0364-5134 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33614 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Title | Human T-lymphotropic virus type II and neurological disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1002/ana.20126 | |
| Abstract | Human T-lymphotropic virus type I (HTLV-I) and type II (HTLV-II) are closely related retroviruses with similar bio-logical properties and common modes of transmission. HTLV-I infection is endemic in well-defined geographic regions,and it is estimated that some 20 million individuals are infected worldwide. Although most infected individuals areasymptomatic carriers, some 2 to 5% will develop a chronic encephalomyelopathy, HTLV-I–associated myelopathy/tropical spastic paraparesis (HAM/TSP). In contrast with HTLV-I, the role of HTLV-II in the development of neuro-logical disorders is much less clear. HTLV-II is endemic in many native Amerindian groups and epidemic in injectingdrug users (IDUs) worldwide. To evaluate the role of HTLV-II in neurological disease, we have critically reviewed allreported cases of HTLV-II–associated disorders. This has confirmed that although rare infection is associated with adisorder clinically similar or identical to HAM/TSP. However, most reports that have attributed infection to a range ofother neurological disorders are difficult to evaluate in that in many cases either the association appears to be fortuitousor the presentations were confounded by a background of concomitant human immunodeficiency virus–1 infectionand/or active IDU. In view of the many HTLV-II–infected individuals in urban areas of North America and Europe,neurologists should be aware of the potential clinical consequences of this infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / University College Dublin. Conway Institute of Biomolecular and Biomedical Research. Department of Medical Microbiology. Dublin, Ireland. | pt_BR |
| Affilliation | University College Dublin. Conway Institute of Biomolecular and Biomedical Research. Department of Medical Microbiology. Dublin, Ireland. | pt_BR |
| Subject | HTLV-I | pt_BR |
| Subject | HTLV-II | pt_BR |
| Subject | Neurological disease | pt_BR |
| e-ISSN | 1531-8249 | |
| Embargo date | 2020-06-21 | |
