Author | Nishikawa, M. M. | |
Author | Lazéra, M. S. | |
Author | Barbosa, G. G. | |
Author | Trilles, L. | |
Author | Balassiano, B. R. | |
Author | Macêdo, R. C. | |
Author | Bezerra, C. C. | |
Author | Perez, M. A. | |
Author | Leite, P. | |
Author | Wanke, B. | |
Access date | 2019-06-24T12:58:59Z | |
Available date | 2019-06-24T12:58:59Z | |
Document date | 2003 | |
Citation | NISHIKAWA, Marília M. et al. Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns. Journal of Clinical Microbiology, v. 41, n. 1, p. 73-77, 2003. | pt_BR |
ISSN | 0095-1137 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33629 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/jcm.41.1.73-77.2003 | |
Abstract | Cryptococcus neoformans is an important zoopathogen, and it is one of the most prevalent lethal mycotic agents. Its polysaccharide capsule, synthesized in vivo and in vitro, is a virulence factor, contains predominantly glucuronoxylomannan, and is responsible for the antigenic differentiation of serotypes A, B, C, D, and AD. A total of 467 isolates of C. neoformans obtained from clinical and environmental sources from Brazilian regions were studied serologically by using the Crypto Check Iatron RM 304-K kit. Serotyping of the clinical isolates showed the following prevalences of the serotypes: A (77.95%), followed by B (18.2%), AD (1.3%), D (0.4%), C (0.2%), and untypeable (1.93%). The epidemiology of serotype A in the Brazilian southern and southeastern regions reproduces the picture observed worldwide. In contrast, serotype B was the most frequent agent of cryptococcosis in the northeastern region, occurring nearly equally in male and female healthy hosts. Among the isolates from environmental sources, serotypes A and B were found to occur in the hollows of tropical trees of the genera Cassia, Ficus, and Moquillea. The few isolates from Eucalyptus camaldulensis debris were serotypes A and B and untypeable. Overall, no association with a specific host tree was identified for these serotypes, denoting a distinct ecoepidemiological regional pattern. The one serotype C isolate was recovered from a human immunodeficiency virus-negative host. Serotype AD predominated over serotype D among both clinical and environmental isolates. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Federal University of Rio de Janeiro. Center of Community Health Studies. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Cryptococcus neoformans | pt_BR |
Subject | Serotyping | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1098-660X | |
Embargo date | 2019-12-24 | |