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AuthorKano, Flora Satiko
AuthorSouza, Aracele Maria de
AuthorTorres, Leticia de Menezes
AuthorCosta, Marcelo Azevedo
AuthorSilva, Flávia Alessandra Souza
AuthorSanchez, Bruno Antônio Marinho
AuthorFontes, Cor Jesus Fernandes
AuthorSoares, Irene Silva
AuthorBrito, Cristiana Ferreira Alves de
AuthorCarvalho, Luzia Helena de
AuthorSousa, Tais Nobrega
Access date2019-06-24T16:24:09Z
Available date2019-06-24T16:24:09Z
Document date2018
CitationKANO, Flora Satiko et al. Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria. Scientific Reports, v. 8, p. 1-14, 2018.pt_BR
ISSN2045-2322pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/33634
Languageengpt_BR
PublisherNature Researchpt_BR
Rightsopen accesspt_BR
Subject in Portuguesebiologia parasitariapt_BR
Subject in Portugueseinteração hospedeiro parasitapt_BR
TitleSusceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malariapt_BR
TypeArticlept_BR
DOI10.1038/s41598-018-32254-z
AbstractMalaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Africa and confers resistance to Plasmodium vivax infection. Here, we showed the influence of genomic ancestry on the distribution of DARC genotypes in a highly admixed Brazilian population and confirmed the decreased susceptibility of the FY*A/FY*O genotype to clinical P. vivax malaria. FY*B/FY*O individuals were associated with a greater risk of developing clinical malaria. A remarkable difference among DARC variants concerning the susceptibility to clinical malaria was more evident for individuals who were less exposed to malaria, as measured by the time of residence in the endemic area. Additionally, we found that DARC-negative and FY*A/FY*O individuals had a greater chance of acquiring high levels of antibodies against the 19-kDa C-terminal region of the P. vivax merozoite surface protein-1. Altogether, our results provide evidence that DARC polymorphisms modulate the susceptibility to clinical P. vivax malaria and influence the naturally-acquired humoral immune response to malaria blood antigens, which may interfere with the efficacy of a future vaccine against malaria.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
AffilliationUniversidade Federal de Minas Gerais. Departamento de Engenharia de Produção. Belo Horizonte, MG, Brasil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
AffilliationUniversidade Federal de Mato Grosso. Cuiabá, MT, Brasil.pt_BR
AffilliationUniversidade Federal de Mato Grosso. Hospital Julio Muller. Cuiabá, MT, Brazil.pt_BR
AffilliationUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brazil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.pt_BR
SubjectParasite biologypt_BR
SubjectParasite host responsept_BR


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