| Author | Valle, Denise | |
| Author | Bellinato, Diogo Fernandes | |
| Author | Medeiros, Priscila Fernandes Viana | |
| Author | LIma, José Bento Pereira | |
| Author | Martins Junior, Ademir de Jesus | |
| Access date | 2019-06-25T11:24:18Z | |
| Available date | 2019-06-25T11:24:18Z | |
| Document date | 2019 | |
| Citation | VALLE, Denise et al. Resistance to temephos and deltamethrin in Aedes aegypti from Brazil between 1985 and 2017. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-17, 2019. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33645 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Aedes aegypti | pt_BR |
| Subject in Portuguese | Resistência à inseticidas | pt_BR |
| Subject in Portuguese | Controle de vetores | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Deltametrina | pt_BR |
| Subject in Portuguese | Temefos | pt_BR |
| Title | Resistance to temephos and deltamethrin in Aedes aegypti from Brazil between 1985 and 2017 | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760180544 | pt_BR |
| Abstract | BACKGROUND Aedes aegypti populations in Brazil have been subjected to insecticide selection pressures with variable levels
and sources since 1967. Therefore, the Brazilian Ministry of Health (MoH) coordinated the activities of an Ae. aegypti insecticide
resistance monitoring network (MoReNAa) from 1999 to 2012.
OBJECTIVES The objective of this study was to consolidate all information available from between 1985 and 2017 regarding
the resistance status and mechanisms of Brazilian Ae. aegypti populations against the main insecticide compounds used at the
national level, including the larvicide temephos (an organophosphate) and the adulticide deltamethrin (a pyrethroid).
METHODS Data were gathered from two sources: a bibliographic review of studies published from 1985 to 2017, and unpublished
data produced by our team within the MoReNAa between 1998 and 2012. A total of 146 municipalities were included, many of
which were evaluated several times, totalling 457 evaluations for temephos and 274 for deltamethrin. Insecticide resistance data
from the five Brazilian regions were examined separately using annual records of both the MoH supply of insecticides to each
state and the dengue incidence in each evaluated municipality.
FINDINGS Ae. aegypti resistance to temephos and deltamethrin, the main larvicide and adulticide, respectively, employed
against mosquitoes in Brazil for a long time, was found to be widespread in the country, although with some regional variations.
Comparisons between metabolic and target-site resistance mechanisms showed that one or another of these was the main
component of pesticide resistance in each studied population.
MAIN CONCLUSIONS (i) A robust dataset on the assessments of the insecticide resistance of Brazilian Ae. aegypti populations
performed since 1985 was made available through our study. (ii) Our findings call into question the efficacy of chemical control
as the sole methodology of vector control. (iii) It is necessary to ensure that sustainable insecticide resistance monitoring is
maintained as a key component of integrated vector management. (iv) Consideration of additional parameters, beyond the
supply of insecticides distributed by the MoH or the diverse local dynamics of dengue incidence, is necessary to find consistent
correlations with heterogeneous vector resistance profiles. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército, Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Aedes aegypti | pt_BR |
| Subject | Inseticide resitance | pt_BR |
| Subject | Temephos | pt_BR |
| Subject | Deltametrin | pt_BR |
| Subject | Vector control | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1678-8060 | |
