| Author | Martins, Tassiane Assiria Fontes | |
| Author | Barbosa, Vitor Silva | |
| Author | Almeida, Gregório Guilherme | |
| Author | Antonelli, Lis Ribeiro Do Valle | |
| Author | Tafuri, Wagner Luiz | |
| Author | Mosser, David M. | |
| Author | Gonçalves, Ricardo | |
| Access date | 2019-07-01T13:54:15Z | |
| Available date | 2019-07-01T13:54:15Z | |
| Document date | 2018 | |
| Citation | MARTINS, Tassiane Assiria Fontes et al. Monocyte subpopulations as important biomarkers of resistence and susceptibility during experimental infection with Leishmania (Leishmania) major. Biomedicine & Pharmacotherapy, v. 107, p. 1530-1539, 2018. | pt_BR |
| ISSN | 0753-3322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33748 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Subpopulação de monócitos | pt_BR |
| Subject in Portuguese | Biomarcadores | pt_BR |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Resistência | pt_BR |
| Subject in Portuguese | Suscetibilidade | pt_BR |
| Title | Monocyte subpopulations as important biomarkers of resistence and susceptibility during experimental infection with Leishmania (Leishmania) major | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.biopha.2018.08.154 | |
| Abstract | Visceral Leishmaniasis is a chronic and lethal, parasitic disease. In the later infection stages, it is known that expressive hematological disorders can be observed, including changes in the frequency and phenotype of certain leukocytes. There is a lack of good prognostic indicators to characterize the on-goin clinical status of the patient. In this study, we have analyzed the frequency of monocyte subpopulations in mice infected with Leishmania major (L. major). Our results show a significant correlation between increased blood monocyte frequency and lesion development in both BALB/c and in the C57BL/6 mice infected with L. major. In BALB/c mice we observed a significant correlation between the frequency of GR1+ monocytes and lesion size. Furthermore, treatment of infected BALB/c mice with Anfotericin B, to resolve lesions, resulted in a lower frequency of GR1+ monocytes compared to untreated infected BALB/c mice. C57BL/6 infected mice, which normally resolve infections, show decreased numbers of monocytes during the healing phase of infection. The results indicate that disease severity can be predicted by analyzing monocyte frequency. Thus, we propose that the frequency of monocytes, can be used to define the severity of the disease as well as the success of the treatment in experimental leishmaniasis. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | University of Maryland. College Park. Department of Cell Biology and Molecular Genetics. MD, USA/University of Maryland. College Park. Maryland Pathogen Research Institute. MD, USA / University of Maryland. College Park. Center for Bioinformatics and Computational Biology, University of Maryland. College Park. MD, USA. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Monocyte subpopulation | pt_BR |
| Subject | Biomarkers | pt_BR |
| Subject | Leishmania | pt_BR |
| Subject | Resistance | pt_BR |
| Subject | Susceptibility | pt_BR |
| Embargo date | 2025-01-01 | |
