| Author | Yeganeh, Nava | |
| Author | Watts, D. Heather | |
| Author | Xu, Jiahong | |
| Author | Kerin, Tara | |
| Author | Joao, Esau C. | |
| Author | Pilotto, Jose Henrique | |
| Author | Theron, Gerhard | |
| Author | Gray, Glenda | |
| Author | Santos, Breno | |
| Author | Fonseca, Rosana | |
| Author | Kreitchmann, Regis | |
| Author | Pinto, Jorge | |
| Author | Mussi-Pinhata, Marisa M. | |
| Author | Veloso, Valdiléa G. | |
| Author | Camarca, Margaret | |
| Author | Mofenson, Lynne | |
| Author | Moye, Jack | |
| Author | Nielsen-Saines, Karin | |
| Access date | 2019-07-02T14:11:35Z | |
| Available date | 2019-07-02T14:11:35Z | |
| Document date | 2018 | |
| Citation | YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, v. 37, n. 12, p. 1271-1278, Dec. 2018. | pt_BR |
| ISSN | 0891-3668 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33773 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Previous version | https://www.arca.fiocruz.br/handle/icict/29114 | |
| Rights | open access | |
| Title | Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial | pt_BR |
| Type | Article | |
| DOI | 10.1097/INF.0000000000002082 | |
| Abstract | Background: HIV-exposed uninfected (HEU) infants are a growing population with potentially poor health outcomes. We evaluated morbidity and mortality in HEU formula-fed infants enrolled in the NICHD HPTN 040/PACTG 1043 trial. Methods: Infectious morbidity, mortality and undernutrition were evaluated within a cohort of 1000 HEU infants enrolled between April 2004 and April 2010 in Brazil (n = 766) and South Africa (n = 234) as part of the NICHD/HPTN 040 trial of 3 different antiretroviral regimens to decrease intrapartum HIV vertical transmission. Results: Twenty-three percent of infants had at least 1 infectious serious adverse effect. Infants born to mothers with <12 years of education [adjusted odds ratio (AOR), 2.6; 95% confidence interval [CI], 1.2-5.9), with maternal viral load of >1,000,000 copies/mL at delivery (AOR, 9.9; 95% CI, 1.6-63.1) were more likely to have infectious serious adverse effects. At 6 months, the infant mortality rate per 1000 live births overall was 22 ± 2.6, 9.1 ± 1.8 in Brazil and 64.1 ± 3 in South Africa. Undernutrition and stunting peaked at 1 month of age with 18% having a weight-for-age Z score ≤-2, and 22% with height for Z score ≤-2. The likelihood of infant mortality was greater among infants born in South Africa compared with Brazil (AOR, 6.2; 95% CI, 2.5-15.8), high maternal viral load (AOR, 1.7; 95% CI, 1.01-2.9) and birth weight-for-age Z score ≤-2 (AOR, 5.2; 95% CI, 1.8-14.8). Conclusions: There were high rates of undernutrition, stunting and infectious serious adverse effect in this study's formula-fed HEU population. Suppressing maternal HIV viral load during the peripartum period may be a modifiable risk factor to decrease infant mortality. | pt_BR |
| Affilliation | University of California, Los Angeles. David Geffen School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | US Department of State. Office of the Global AIDS Coordinator and Health Diplomacy. Washington, DC, USA. | pt_BR |
| Affilliation | Westat. Rockville, MD, USA. | pt_BR |
| Affilliation | University of California, Los Angeles. David Geffen School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Stellenbosch University. Perinatal HIV Research Unit. Cape Town, South Africa / Tygerberg Hospital. Cape Town, South Africa. | pt_BR |
| Affilliation | University of Witwatersrand. Johannesburg, South Africa / Chris Hani Baragwanath Hospital, Johannesburg, South Africa. | pt_BR |
| Affilliation | Hospital Conceição. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Hospital Femina. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Irmandade da Santa Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade de São Paulo. Ribeirão Preto, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Westat. Rockville, MD, USA. | pt_BR |
| Affilliation | Elisabeth Glaser Pediatric AIDS Foundation. Washington, DC, USA. | pt_BR |
| Affilliation | National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA. | pt_BR |
| Affilliation | University of California, Los Angeles. David Geffen School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Subject | HIV exposed | pt_BR |
| Subject | Uninfected infants | pt_BR |
| Subject | Formula feeding | pt_BR |
| Subject | Undernutrition | pt_BR |
| e-ISSN | 1532-0987 | |
| Embargo date | 2020-07-02 | |
