| Author | Golbert, Daiane Cristina Ferreira | |
| Author | Santana, Eliane Correa de | |
| Author | Alves, Marcelo Ribeiro | |
| Author | Vasconcelos, Ana Tereza Ribeiro de | |
| Author | Savino, Wilson | |
| Access date | 2019-07-04T15:51:58Z | |
| Available date | 2019-07-04T15:51:58Z | |
| Document date | 2013 | |
| Citation | GOLBERT, Daiana Cristina Ferreira et al. ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells. BMC Genomics, v. 14, Suppl. 6, n. 53, p.1-9, 2013. | pt_BR |
| ISSN | 1471-2164 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33844 | |
| Description | From 8th International Conference of the Brazilian Association for Bioinformatics and Computational Biology (X-meeting 2012). Campinas, Brazil. 14-17 October 2012. | pt_BR |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Gene ITGA 6 | pt_BR |
| Subject in Portuguese | Células epitelias humanas | pt_BR |
| Subject in Portuguese | Migração celular | pt_BR |
| Subject in Portuguese | RNA | pt_BR |
| Subject in Portuguese | Timo | pt_BR |
| Title | ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells | pt_BR |
| Type | Article | |
| DOI | 10.1186/1471-2164-14-S6-S3 | pt_BR |
| Abstract | The thymic epithelium is the major microenvironmental component of the thymus, the primary lymphoid organ responsible for the generation of T lymphocytes. Thymic epithelial cells (TEC) control intrathymic T cell differentiation by means of distinct types of interactions. TEC constitutively produce chemokines and extracellular matrix ligands (such as laminin and fibronectin) and express corresponding receptors, which allow thymocytes to migrate in a very ordered fashion. We previously showed that laminin mediates TEC/thymocyte interactions in both mice and humans. More recently, we used RNAi technology to knock-down the ITGA5 gene (which encodes CD49e, the integrin a-chain subunit of the fibronectin receptor VLA-5) in cultured human TEC. Using a similar strategy, herein we nocked-down the ITGA6 gene, which encodes CD49f, the a-chain of two integrin-type laminin receptors, namely VLA-6 (a6b1) and a6b4. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Laboratório Nacional de Computação Científica. Laboratório de Bioinformática. Petrópolis, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Laboratório Nacional de Computação Científica. Laboratório de Bioinformática. Petrópolis, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | ITGA6 gene | pt_BR |
| Subject | RNA | pt_BR |
| Subject | Cell migration | pt_BR |
| Subject | Human thymic epithelial cells | pt_BR |
| Subject | Thymus | pt_BR |
