| Author | Cruz, Daniella Arêas Mendes da | |
| Author | Silva, João Santana | |
| Author | Almeida, Vinícius Cotta de | |
| Author | Savino, Wilson | |
| Access date | 2019-07-04T16:50:30Z | |
| Available date | 2019-07-04T16:50:30Z | |
| Document date | 2006 | |
| Citation | CRUZ, Daniela Arêas Mendes da et al. Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4. Eur. J. Immunol., v. 36, p. 1486-1493, 2006. | pt_BR |
| ISSN | 0014-2980 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33850 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Quimiocinas | pt_BR |
| Subject in Portuguese | Matriz extracelular | pt_BR |
| Subject in Portuguese | Migração de timócitos | pt_BR |
| Subject in Portuguese | Timo | pt_BR |
| Title | Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4 | pt_BR |
| Type | Article | |
| DOI | 10.1002/eji.200535629 | pt_BR |
| Abstract | We previously showed migration disturbances in the thymus during experimental infection with Trypanosoma cruzi, the causative agent of Chagas disease. These changes were related to the enhanced expression of extracellular matrix ligands and receptors, leading to the escape of immature cells to the periphery. Here, we analyzed the expression and role of selected chemokines (CXCL12 and CCL4) and their receptors
(CXCR4 and CCR5) in regulating thymocyte migration in conjunction with extracellular matrix during acute T. cruzi infection. We found increased chemokine deposition in the thymus of infected mice when compared to controls, accompanied by enhanced colocalization with fibronectin as well as up-regulated surface expression of CXCR4 and CCR5 in thymocytes. We also noticed altered thymocyte migration towards the chemokines analyzed. Such an enhancement was even more prominent when
fibronectin was added as a haptotatic stimulus in combination with a given chemokine. Our findings suggest that thymocyte migration results from a combined action of chemokines and extracellular matrix (ECM), which can be altered during pathological conditions such as T. cruzi infection, and may be at the origin of the changes in the Tcell repertoire seen in this pathological process. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | Extracellular matrix | pt_BR |
| Subject | Thymocite migration | pt_BR |
| Subject | Thymus | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| e-ISSN | 1521-4141 | |
| Embargo date | 2022-01-01 | |
