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| Autor | Cerávolo, Isabela Penna | |
| Autor | Zani, Carlos Leomar | |
| Autor | Figueiredo, Flávio Júnior Barbosa | |
| Autor | Kohlhoff, Markus | |
| Autor | Santana, Antônio Euzébio Goulart | |
| Autor | Krettli, Antoniana Ursine | |
| Fecha de acceso | 2019-07-04T17:30:10Z | |
| Fecha de disponibilización | 2019-07-04T17:30:10Z | |
| Fecha de publicación | 2018 | |
| Referencia | CERÁVOLO, Isabela Pena et al. Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity. Malaria Journal, v. 17, n. 1, p. 1-11, 2018. | pt_BR |
| ISSN | 1475-2875 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33854 | |
| Idioma | eng | pt_BR |
| Editor | BioMed Central | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Anti-malaricos | pt_BR |
| Palabras clave en Portugués | Aspidosperma pyrifolium | pt_BR |
| Palabras clave en Portugués | Etnofarmacologia | pt_BR |
| Palabras clave en Portugués | Plantas medicinais | pt_BR |
| Palabras clave en Portugués | Plasmodium falciparum | pt_BR |
| Título | Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1186/s12936-018-2568-y | |
| Resumen en Inglés | BACKGROUND: Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflammatory. Its fractionated extracts were assayed in vitro for activity against malaria parasites and for cytotoxicity. METHODS: Aspidosperma pyrifolium activity was evaluated against Plasmodium falciparum using extracts in vitro. Toxicity towards human hepatoma cells, monkey kidney cells or human monocytes freshly isolated from peripheral blood was also assessed. Anti-malarial activity of selected extracts and fractions that presented in vitro activity were tested in mice with a Plasmodium berghei blood-induced infection. RESULTS: The crude stem bark extract and the alkaloid-rich and ethyl acetate fractions from stem extract showed in vitro activity. None of the crude extracts or fractions was cytotoxic to normal monkey kidney and to a human hepatoma cell lines, or human peripheral blood mononuclear cells; the MDL50 values of all the crude bark extracts and fractions were similar or better when tested on normal cells, with the exception of organic and alkaloidic-rich fractions from stem extract. Two extracts and two fractions tested in vivo caused a significant reduction of P. berghei parasitaemia in experimentally infected mice. CONCLUSION: Considering the high therapeutic index of the alkaloidic-rich fraction from stem extract of A. pyrifolium, it makes the species a candidate for further investigation aiming to produce a new anti-malarial, especially considering that the active extract has no toxicity, i.e., no mutagenic effects in the genototoxicity assays, and that it has an in vivo anti-malarial effect. In its UPLC-HRMS analysis this fraction was shown to have two major components compatible with the bisindole alkaloid Leucoridine B, and a novel compound, which is likely to be responsible for the activity against malaria parasites demonstrated in in vitro tests. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Quimica de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Quimica de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Afiliación | Universidade Federal de Alagoas. Centro de Ciências Agrárias. Maceió, AL, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil. | pt_BR |
| Palavras clave en Inglês | Anti-malarial | pt_BR |
| Palavras clave en Inglês | Aspidosperma pyrifolium | pt_BR |
| Palavras clave en Inglês | Ethnopharmacology | pt_BR |
| Palavras clave en Inglês | Medicinal plants | pt_BR |
| Palavras clave en Inglês | Plasmodium falciparum | pt_BR |
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