| Author | Borges, Juliana P. | |
| Author | Nascimento, Alessandro R. | |
| Author | Lopes, Gabriella O. | |
| Author | Medeiros-Lima, Daniel J. M. | |
| Author | Coelho, Marina P. | |
| Author | Nascimento, Pablo M. C. | |
| Author | Kopiler, Daniel A. | |
| Author | Matsuura, Cristiane | |
| Author | Mediano, Mauro Felippe F. | |
| Author | Tibirica, Eduardo | |
| Access date | 2019-07-15T12:39:51Z | |
| Available date | 2019-07-15T12:39:51Z | |
| Document date | 2018 | |
| Citation | BORGES, Juliana P. et al. The impact of exercise frequency upon microvascular endothelium function and oxidative stress among patients with coronary artery disease. Clinical Physiology and Functional Imaging, v. 38, p. 840-846, 2018. | pt_BR |
| ISSN | 1475-0961 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34069 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | |
| Title | The impact of exercise frequency upon microvascular endothelium function and oxidative stress among patients with coronary artery disease | pt_BR |
| Type | Article | |
| DOI | 10.1111/cpf.12492 | |
| Abstract | Purpose: This study compared the effects of low and high weekly exercise frequencies on microvascular endothelium function and oxidative stress among patients with coronary artery disease. Methods: Thirty-four male patients completed a 6-month cardiac rehabilitation programme, from which 23 performed exercise with a high frequency (HF) and 11with a low frequency (LF). Systemic microvascular blood flow, maximal aerobic capacity, blood lipids, oxidative stress and anthropometric data were assessed prior to and after the cardiac rehabilitation programme. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine.ResultsMaximal aerobic capacity, biochemical analysis and anthropometric data were similar between groups prior to and after the cardiac rehabilitation programme (P>0 05). However, after 6 months of cardiac rehabilitation performedwith HF, there was an increase in the peak response to acetylcholine compared with LF (83 5 58 5 versus 21 8 22 4%;P<0 05). Changes in lipid peroxida-tion (HF: 5 5 9 4 versus LF: 2 2 12 0 pmol MDA mg 1;P=0 19), cata-lase activity (HF: 0 07 0 17 versus LF: 0 04 0 08 U mg 1;P=0 74) andnitric oxide levels (HF: 1 8 15 3 versus LF: 3 2 12 3lM;P=0 36) were similar between groups after cardiac rehabilitation. Conclusion: Six months of aerobic exercise training performed with high frequencyis preferable to low frequency aiming endothelium microvascular function increases in patients with coronary artery disease. The mechanisms involved in this response are unclear and warrant additional research. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil / Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | State University of Rio de Janeiro. Department of Pharmacology and Psychobiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil | pt_BR |
| Affilliation | Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil | pt_BR |
| Affilliation | State University of Rio de Janeiro. Department of Pharmacology and Psychobiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cardiac rehabilitation | pt_BR |
| Subject | Endothelial function | pt_BR |
| Subject | Exercise volume | pt_BR |
| Subject | Ischaemic heart disease | pt_BR |
| Subject | Laser specklecontrast imaging | pt_BR |
| Subject | Microvascular flowmetry | pt_BR |
| e-ISSN | 1475-097X | |
| Embargo date | 2020-07-15 | |
