Author | Meira, Cássio Santana | |
Author | Santos, Emanuelle de Souza | |
Author | Santo, Renan Fernandes do Espírito | |
Author | Vasconcelos, Juliana Fraga | |
Author | Orge, Iasmim Diniz | |
Author | Nonaka, Carolina Kymie Vasques | |
Author | Barreto, Breno Cardim | |
Author | Caria, Alex Cleber Improta | |
Author | Silva, Daniela Nascimento | |
Author | Barbosa Filho, José Maria | |
Author | Macambira, Simone Garcia | |
Author | Moreira, Diogo Rodrigo Magalhães | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2019-07-15T18:59:49Z | |
Available date | 2019-07-15T18:59:49Z | |
Document date | 2019 | |
Citation | MEIRA, Cassio Santana et al. Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization. Frontiers in Immunology, p. 1-9, June 2019. | pt_BR |
ISSN | 1664-3224 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34117 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Derivado do ácido betulínico | pt_BR |
Subject in Portuguese | Imunomodulação | pt_BR |
Subject in Portuguese | Doença de chagas | pt_BR |
Subject in Portuguese | Cardiomiopatia | pt_BR |
Title | Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fimmu.2019.01257 | |
Abstract | Chronic Chagas disease cardiomyopathy (CCC) is a major cause of heart disease in Latin America and treatment for this condition is unsatisfactory. Here we investigated the effects of BA5, an amide semi-synthetic derivative betulinic acid, in a model of CCC. Mice chronically infected with T. cruzi were treated orally with BA5 (10 or 1 mg/Kg), three times per week, for 2 months. BA5 treatment decreased inflammation and fibrosis in heart sections but did not improve exercise capacity or ameliorate cardiac electric disturbances in infected mice. Serum concentrations of TNF-α, IFN-γ, and IL-1β, as well as cardiac gene expression of pro-inflammatory mediators, were reduced after BA5 treatment. In contrast, a significant increase in the anti-inflammatory cytokine IL-10 concentration was observed in BA5-treated mice in both tested doses compared to vehicle-treated mice. Moreover, polarization to anti-inflammatory/M2 macrophage phenotype was evidenced by a decrease in the expression of NOS2 and proinflammatory cytokines and the increase in M2 markers, such as Arg1 and CHI3 in mice treated with BA5. In conclusion, BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease related to IL-10 production and a switch from M1 to M2 subset of macrophages. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Science and Health Institute. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Paraíba. Laboratory of Pharmaceutical Technology. João Pessoa, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Science and Health Institute. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Betulinic acid derivative | pt_BR |
Subject | Immunomodulation | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Cardiomyopathy | pt_BR |