| Author | Faria Neto, Hugo Caire C. | |
| Author | Stafforini, Diana M. | |
| Author | Prescott, Stephen M. | |
| Author | Zimmerman, Guy A. | |
| Access date | 2019-07-23T12:10:11Z | |
| Available date | 2019-07-23T12:10:11Z | |
| Document date | 2005 | |
| Citation | FARIA NETO, Hugo Caire C. et al. Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. I, p. 83-91, 2005. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34332 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Sepse | pt_BR |
| Subject in Portuguese | Doença inflamatória | pt_BR |
| Subject in Portuguese | Acetil-hidrolase | pt_BR |
| Subject in Portuguese | Fator de ativação de plaquetas | pt_BR |
| Title | Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase | pt_BR |
| Type | Article | |
| DOI | 10.1590/s0074-02762005000900014 | |
| Abstract | Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Utah. The Huntsman Cancer Institute. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. The Huntsman Cancer Institute. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. The Huntsman Cancer Institute. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA. | pt_BR |
| Subject | Platelet-activating factor | pt_BR |
| Subject | Acethylhydrolase | pt_BR |
| Subject | Inflammatory disease | pt_BR |
| Subject | Sepsis | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
