Author | Castro, R. R. T. | |
Author | Porphirio, G. | |
Author | Xavier, S. S. | |
Author | Moraes, R. S. | |
Author | Ferlin, E. L. | |
Author | Ribeiro, J. P. | |
Author | Nóbrega, A. C. L. da | |
Access date | 2019-07-23T14:44:34Z | |
Available date | 2019-07-23T14:44:34Z | |
Document date | 2017 | |
Citation | CASTRO, Renata R. T. et al. Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease. Cardiovascular Therapeutics, v. 35, p. 1-5, 2017. | pt_BR |
ISSN | 1755-5914 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34351 | |
Description | Sergio S. Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Title | Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/1755-5922.12288 | |
Abstract | Introduction: Parasympathetic dysfunction may play a role in the genesis of arrhyth-mias in Chagas disease. Aim: This study evaluates the acute effects of pyridostigmine (PYR), a reversible cholinest-erase inhibitor, on the occurrence of arrhythmias in patients with Chagas cardiac disease. Method: Following a double-blind, randomized, placebo- controlled, cross- over proto-col, 17 patients (age 50±2 years) with Chagas cardiac disease type B underwent 24- hour Holter recordings after oral administration of either pyridostigmine bromide (45 mg, 3 times/day) or placebo (PLA).Results: Pyridostigmine reduced the 24- hours incidence (median [25%- 75%]) of pre-mature ventricular beats—PLA: 2998 (1920- 4870), PYR: 2359 (940- 3253), P=.044; ventricular couplets—PLA: 84 (15- 159), PYR: 33 (6- 94), P=.046. Although the total number of nonsustained ventricular tachycardia in the entire group was not different (P=.19) between PLA (1 [0- 8]) and PYR (0 [0- 4]), there were fewer episodes under PYR in 72% of the patients presenting this type of arrhythmia (P=.033). Conclusion: Acute administration of pyridostigmine reduced the incidence of nonsus-tained ventricular arrhythmias in patients with Chagas cardiac disease. Further studies that address the use of pyridostigmine by patients with Chagas cardiac disease under a more prolonged follow- up are warranted. | pt_BR |
Affilliation | Fluminense Federal University. Department of Physiology and Pharmacology and Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | pt_BR |
Affilliation | Rio de Janeiro Federal University. Division of Cardiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Rio de Janeiro Federal University. Division of Cardiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Rio Grande do Sul Federal University. Division of Cardiology. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Rio Grande do Sul Federal University. Division of Cardiology. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Rio Grande do Sul Federal University. Division of Cardiology. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Fluminense Federal University. Department of Physiology and Pharmacology and Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | pt_BR |
Subject | Antiarrhythmia drugs | pt_BR |
Subject | Arrhythmia | pt_BR |
Subject | Autonomic diseases | pt_BR |
Subject | Chagas cardiomyopathy | pt_BR |
Subject | Cholinesterases | pt_BR |
Subject | Parasympathetic nervous system | pt_BR |
e-ISSN | 1755-5922 | |
Embargo date | 2020-07-23 | |