Author | Rossi, Erik Aranha | |
Author | Quintanilha, Luiz Fernando | |
Author | Nonaka, Carolina Kymie Vasques | |
Author | Souza, Bruno Solano de Freitas | |
Access date | 2019-07-31T18:24:52Z | |
Available date | 2019-07-31T18:24:52Z | |
Document date | 2019 | |
Citation | ROSSI, Erik Aranha et al. Advances in Hepatic Tissue Bioengineering with Decellularized Liver Bioscaffold. Stem Cells International, v. 2019, p. 1-13, 2019. | pt_BR |
ISSN | 1687-966X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34550 | |
Sponsorship | National Institute of Science and Technology for Regenerative Medicine. | pt_BR |
Language | eng | pt_BR |
Publisher | Hindwai | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Bioengenharia | pt_BR |
Subject in Portuguese | Fígado | pt_BR |
Subject in Portuguese | Transplante de fígado | pt_BR |
Subject in Portuguese | Celulas | pt_BR |
Title | Advances in Hepatic Tissue Bioengineering with Decellularized Liver Bioscaffold | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2019/2693189 | |
Abstract | The burden of liver diseases continues to grow worldwide, and liver transplantation is the only option for patients with end-stage liver disease. This procedure is limited by critical issues, including the low availability of donor organs; thus, novel therapeutic strategies are greatly needed. Recently, bioengineering approaches using decellularized liver scaffolds have been proposed as a novel strategy to overcome these challenges. The aim of this systematic literature review was to identify the major advances in the field of bioengineering using decellularized liver scaffolds and to identify obstacles and challenges for clinical application. The main findings of the articles and each contribution for technique optimization were highlighted, including the protocols of perfusion and decellularization, duration, demonstration of quality control-scaffold acellularity, matrix composition, and preservation of growth factors-and tissue functionality after recellularization. In previous years, many advances have been made as this technique has evolved from studies in animal models to human livers. As the field develops and this promising technique has become much more feasible, many challenges remain, including the selection of appropriate cell types for recellularization, route of cell administration, cell-seeding protocol, and scalability that must be standardized prior to clinical application. | pt_BR |
Affilliation | Universidade de Salvador. Escola de Ciências da Saúde. Salvador, BA, Brasil / São Rafael Hospital. D’Or Institute for Research and Education. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade de Salvador. Escola de Ciências da Saúde. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências, Salvador, BA, Brasil. | pt_BR |
Affilliation | São Rafael Hospital. D’Or Institute for Research and Education. Salvador, BA, Brazil. | pt_BR |
Affilliation | São Rafael Hospital. D’Or Institute for Research and Education. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil. | pt_BR |
Subject | Bioengineering | pt_BR |
Subject | Liver | pt_BR |
Subject | Liver Transplantation | pt_BR |
Subject | Cells | pt_BR |