| Author | Andrade, Hugo Boechat | |
| Author | Shinotsuka, Cassia Righy | |
| Author | Silva, Ivan Rocha Ferreira da | |
| Author | Donini, Camila Sunaitis | |
| Author | Yeh Li, Ho | |
| Author | Carvalho, Frederico Bruzzi de | |
| Author | Brasil, Pedro Emmanuel Alvarenga Americano do | |
| Author | Bozza, Fernando A. | |
| Author | Japiassu, Andre Miguel | |
| Access date | 2019-08-07T13:02:54Z | |
| Available date | 2019-08-07T13:02:54Z | |
| Document date | 2017 | |
| Citation | ANDRADE, Hugo Boechat et al. Highly active antiretroviral therapy for critically ill HIV patients: a systematic review and meta-analysis. Plos One, p. 1-12, Oct. 2017. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34644 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Highly active antiretroviral therapy for critically ill HIV patients: a systematic review and meta-analysis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0186968 | |
| Abstract | Introduction: It is unclear whether the treatment of an HIV infection with highly active antiretroviral therapy (HAART) affects intensive care unit (ICU) outcomes. In this paper, we report the results of a systematic review and meta-analysis performed to summarize the effects of HAART on the prognosis of critically ill HIV positive patients. Materials and methods: A bibliographic search was performed in 3 databases (PubMed, Web of Science and Scopus) to identify articles that investigated the use of HAART during ICU admissions for shortand long-term mortality or survival. Eligible articles were selected in a staged process and were independently assessed by two investigators. The methodological quality of the selected articles was evaluated using the Methodological Index for Non-Randomized Studies (MINORS) tool. Results: Twelve articles met the systematic review inclusion criteria and examined short-term mortality. Six of them also examined long-term mortality ( 90 days) after ICU discharge. The short-term mortality meta-analysis showed a significant beneficial effect of initiating or maintaining HAART during the ICU stay (random effects odds ratio 0.53, p = 0.02). The data analysis of long-term outcomes also suggested a reduced mortality when HAART was used, but the effect of HAART on long-term mortality of HIV positive critically ill patients remains uncertain. Conclusions: This meta-analysis suggests improved survival rates for HIV positive patients who were treated with HAART during their ICU admission. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Infectious Diseases Intensive. São Paulo, SP, Brazil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Infectious Diseases Intensive. São Paulo, SP, Brazil. | pt_BR |
| Affilliation | Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Intensive Care Unit. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV patients | pt_BR |
| Subject | Antiretroviral therapy | pt_BR |
| Subject | HIV | pt_BR |
| e-ISSN | 1932-6203 | |
